GAEC1 gene amplified in esophageal cancer 1 [Homo sapiens (human)] - Gene

Summary

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Gene symbol: GAEC1
Gene description: gene amplified in esophageal cancer 1
Primary source: MIM:612130
Gene type: ncRNA
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Annotation information: not in current annotation release
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Genomic context

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Location:: 7q22.1

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GAEC1 affects mitochondrial respiration by reducing the coupling efficiency in colon adenocarcinoma of the advanced stages (stage III with lymph node metastases). GAEC1 is involved in the interaction between pAkt, FOXO3, and MMP9 in colon adenocarcinoma and may drive the cancer progression through the positive feedback regulation of the Akt/FOXO3/MMP9 signaling pathway.
Title: GAEC1 drives colon cancer progression.
The high expression of GAEC1 mRNA/protein as well as its correlation with multiple clinicopathological characteristics in patients with colorectal carcinoma strongly suggests that GAEC1 is a key regulator in the initiation of colorectal carcinogenesis.
Title: Expression of GAEC1 mRNA and protein and its association with clinical and pathological parameters of patients with colorectal adenocarcinoma.
GAEC1 mutation affects GAEC1 expression and is associated with poorer clinical outcomes in colorectal cancer
Title: GAEC1 mutations and copy number aberration is associated with biological aggressiveness of colorectal cancer.
a xenotransplantation model showed that stable knockdown of GAEC1 using shRNA constructs in colon cancer cells fully suppressed xenograft tumour growth in mice. Collectively, the expression analysis, in vitro and in vivo data indicated that GAEC1 is differentially expressed in cancer cells and act as an oncogene in colon cancer progression
Title: Cellular expression, in-vitro and in-vivo confirmation of GAEC1 oncogenic properties in colon cancer.
GAEC1 regulates the expression of CAPN10 and TNRC6C in esophageal squamous cell carcinoma.
Title: Oncogene GAEC1 regulates CAPN10 expression which predicts survival in esophageal squamous cell carcinoma.
GAEC1 is commonly involved in the pathogenesis of colorectal adenocarcinoma.
Title: GAEC1 and colorectal cancer: a study of the relationships between a novel oncogene and clinicopathologic features.
GAEC1 is a novel tumor transforming gene at 7q22 which encodes a nuclear protein and is frequently amplified and overexpressed in esophageal squamous cell carcinoma.
Title: Identification of a novel tumor transforming gene GAEC1 at 7q22 which encodes a nuclear protein and is frequently amplified and overexpressed in esophageal squamous cell carcinoma.

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NCBI Reference Sequences (RefSeq)

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Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001111040.1: Suppressed sequence

Description

NM_001111040.1: This RefSeq was permanently suppressed because the coding sequence is mostly repetitive sequence.