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RLS4 Restless legs syndrome 4 [ Homo sapiens (human) ]

Gene ID: 100188813, updated on 16-Aug-2019

Summary

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Gene symbol
RLS4
Gene description
Restless legs syndrome 4
Primary source
MIM:610439
Gene type
unknown
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Genomic context

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Location:
2q33

Bibliography

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Related articles in PubMed

  1. Parkin gene modifies the effect of RLS4 on the age at onset of restless legs syndrome (RLS). Pichler I, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jan 5. PMID 19526454
  2. Fine-mapping of restless legs locus 4 (RLS4) identifies a haplotype over the SPATS2L and KCTD18 genes. Pichler I, et al. J Mol Neurosci, 2013 Mar. PMID 23054586

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A haplotype of 23 SNPs spanning 131.6 Kb shared by all affected members of 3 linked families with restless legs syndrome was identified. The shared candidate region covers 46.9 Kb over the potassium channel-related gene KCTD18 and exons 10-13 of SPATS2L.
    Title: Fine-mapping of restless legs locus 4 (RLS4) identifies a haplotype over the SPATS2L and KCTD18 genes.
  2. results suggest that the occurrence of a heterozygous Parkin mutation works in tandem with the gene at the RLS4 locus to lower the age of onset in restless legs syndrome
    Title: Parkin gene modifies the effect of RLS4 on the age at onset of restless legs syndrome (RLS).
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Parkin gene modifies the effect of RLS4 on the age at onset of restless legs syndrome (RLS).
Submit: New GeneRIF Correction

Phenotypes

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Restless legs syndrome 4

General gene information

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Property

  • phenotype only

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