Tmem59 transmembrane protein 59 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmem59provided by RGD
Official Full Name: transmembrane protein 59provided by RGD
Primary source: RGD:1310313
See related: Ensembl:ENSRNOG00000009778 AllianceGenome:RGD:1310313
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Orf18; Shd11; RGD1310313
Summary: Predicted to enable endopeptidase activity. Predicted to be involved in negative regulation of cellular protein metabolic process; negative regulation of protein localization to plasma membrane; and positive regulation of autophagy. Predicted to be located in Golgi cis cisterna; Golgi medial cisterna; and Golgi trans cisterna. Predicted to be active in late endosome and lysosome. Orthologous to human TMEM59 (transmembrane protein 59). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 866.2), Lung (RPKM 616.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (127191320..127212436)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (121962507..121983625)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (126783061..126804177)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sequencing analyses showed that SHD10 shared a 94% (547/581) homology with mouse EST BI687817, but its biological function has not been reported. SHD11 shared a 91% (512/562) homology with mouse EST BG172336.
Title: Discovery of two novel functional genes from differentiation of neural stem cells in the striatum of the fetal rat.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA943736 (e-PCR)
- UniSTS:250178

RH138551 (e-PCR)
- UniSTS:220638

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect protein glycosylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi cis cisterna	ISO Inferred from Sequence Orthology more info
located_in Golgi medial cisterna	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi trans cisterna	ISO Inferred from Sequence Orthology more info
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protein 59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.