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CDH5 cadherin 5 [ Homo sapiens (human) ]

Gene ID: 1003, updated on 4-Jan-2025

Summary

Official Symbol
CDH5provided by HGNC
Official Full Name
cadherin 5provided by HGNC
Primary source
HGNC:HGNC:1764
See related
Ensembl:ENSG00000179776 MIM:601120; AllianceGenome:HGNC:1764
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
7B4; CD144
Summary
This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]
Expression
Biased expression in placenta (RPKM 108.8), lung (RPKM 57.5) and 12 other tissues See more
Orthologs
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Genomic context

See CDH5 in Genome Data Viewer
Location:
16q21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (66366691..66404784)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (72161057..72198985)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66400594..66438687)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371317 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66339117-66339617 Neighboring gene RNA, 5S ribosomal pseudogene 428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66358401-66358938 Neighboring gene uncharacterized LOC105371318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66400487-66401036 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66401847-66402553 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7557 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66404897-66405398 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66406597-66407126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66407769-66408342 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66413378-66414004 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66417102-66417626 Neighboring gene Sharpr-MPRA regulatory region 12004 Neighboring gene long intergenic non-protein coding RNA 920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66462026-66462626 Neighboring gene nuclear envelope phosphatase-regulatory subunit 1-like Neighboring gene brain expressed associated with NEDD4 1 Neighboring gene uncharacterized LOC124903698

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH).
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat C treated human brain microvascular endothelial cells result in downregulation and dissociation of VE-PTP and SHP2 from VE-cadherin PubMed
tat HIV-1 Tat C induces phosphorylation of adherens junction proteins VE-cadherin and beta-catenin in human brain microvascular endothelial cells PubMed
tat Treatment of human brain microvascular endothelial cells with HIV-1 Tat downregulates the expression of VE-cadherin, claudin-5, ZO-1, and occludin proteins in a dose- and time-dependent manner PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ17376

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables BMP receptor binding PubMed 
enables beta-catenin binding  
enables beta-catenin binding PubMed 
enables cadherin binding  
enables calcium ion binding  
enables fibrinogen binding PubMed 
enables protein binding PubMed 
enables protein phosphatase binding  
enables protein phosphatase binding PubMed 
enables protein tyrosine kinase binding PubMed 
enables signaling receptor binding PubMed 
enables signaling receptor complex adaptor activity PubMed 
enables transmembrane transporter binding PubMed 
enables vascular endothelial growth factor receptor 2 binding PubMed 
Items 1 - 25 of 32
Process Evidence Code Pubs
involved_in adherens junction organization  
involved_in adherens junction organization PubMed 
involved_in bicellular tight junction assembly PubMed 
involved_in blood vessel endothelial cell migration PubMed 
involved_in blood vessel maturation  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
involved_in cell migration  
involved_in cell morphogenesis  
involved_in cell-cell adhesion PubMed 
involved_in cell-cell adhesion mediated by cadherin  
involved_in cell-cell adhesion mediated by cadherin PubMed 
involved_in cell-cell junction assembly  
involved_in cell-cell junction assembly PubMed 
involved_in endothelial cell morphogenesis  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules  
involved_in intracellular calcium ion homeostasis PubMed 
involved_in maintenance of blood-brain barrier PubMed 
involved_in negative regulation of cell population proliferation  
acts_upstream_of negative regulation of endothelial cell apoptotic process PubMed 
involved_in negative regulation of inflammatory response PubMed 
involved_in negative regulation of microtubule polymerization PubMed 
involved_in positive regulation of BMP signaling pathway PubMed 
involved_in positive regulation of angiogenesis PubMed 
involved_in positive regulation of cell migration PubMed 
involved_in positive regulation of establishment of endothelial barrier PubMed 
involved_in positive regulation of gene expression PubMed 
involved_in positive regulation of protein-containing complex assembly PubMed 
involved_in protein localization to bicellular tight junction PubMed 
involved_in regulation of establishment of cell polarity PubMed 
involved_in regulation of protein phosphorylation PubMed 
involved_in regulation of vascular permeability PubMed 
involved_in transforming growth factor beta receptor signaling pathway PubMed 
Items 1 - 25 of 32
Component Evidence Code Pubs
is_active_in adherens junction  
located_in adherens junction PubMed 
located_in adherens junction PubMed 
is_active_in bicellular tight junction  
part_of catenin complex  
located_in cell junction  
located_in cell surface PubMed 
located_in cell-cell junction PubMed 
located_in cytoplasm  
located_in external side of plasma membrane  
located_in membrane PubMed 
located_in nuclear membrane  
located_in nucleoplasm  
located_in plasma membrane PubMed 
located_in plasma membrane  

General protein information

Preferred Names
cadherin-5
Names
7B4 antigen
VE-cadherin
cadherin 5, type 2 (vascular endothelium)
cadherin 5, type 2, VE-cadherin (vascular epithelium)
cd144 antigen
endothelial-specific cadherin
vascular endothelial cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001795.5NP_001786.2  cadherin-5 preproprotein

    See identical proteins and their annotated locations for NP_001786.2

    Status: REVIEWED

    Source sequence(s)
    AB209908, BQ716387, X59796, X79981
    Consensus CDS
    CCDS10804.1
    UniProtKB/Swiss-Prot
    P33151, Q4VAI5, Q4VAI6
    UniProtKB/TrEMBL
    Q59EA3
    Related
    ENSP00000344115.3, ENST00000341529.8
    Conserved Domains (4) summary
    cd11304
    Location:156254
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79149
    CA; Cadherin repeats
    pfam00028
    Location:263364
    Cadherin; Cadherin domain
    pfam01049
    Location:633775
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    66366691..66404784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433470.1XP_047289426.1  cadherin-5 isoform X1

    UniProtKB/TrEMBL
    Q59EA3
  2. XM_047433469.1XP_047289425.1  cadherin-5 isoform X1

    UniProtKB/TrEMBL
    Q59EA3
  3. XM_047433471.1XP_047289427.1  cadherin-5 isoform X2

    UniProtKB/Swiss-Prot
    P33151, Q4VAI5, Q4VAI6
    UniProtKB/TrEMBL
    Q59EA3
    Related
    ENSP00000497290.1, ENST00000649567.1
  4. XM_011522801.3XP_011521103.1  cadherin-5 isoform X1

    UniProtKB/TrEMBL
    Q59EA3
    Conserved Domains (4) summary
    cd11304
    Location:156254
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79149
    CA; Cadherin repeats
    pfam00028
    Location:272373
    Cadherin; Cadherin domain
    pfam01049
    Location:635786
    Cadherin_C; Cadherin cytoplasmic region

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    72161057..72198985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379335.1XP_054235310.1  cadherin-5 isoform X1

    UniProtKB/TrEMBL
    Q59EA3
  2. XM_054379334.1XP_054235309.1  cadherin-5 isoform X1

    UniProtKB/TrEMBL
    Q59EA3
  3. XM_054379336.1XP_054235311.1  cadherin-5 isoform X2

    UniProtKB/TrEMBL
    Q59EA3
  4. XM_054379333.1XP_054235308.1  cadherin-5 isoform X1

    UniProtKB/TrEMBL
    Q59EA3

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