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ndst1a N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1a [ Danio rerio (zebrafish) ]

Gene ID: 100329944, updated on 4-Jan-2025

Summary

Official Symbol
ndst1aprovided by ZNC
Official Full Name
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-111012-2
See related
Ensembl:ENSDARG00000062397 AllianceGenome:ZFIN:ZDB-GENE-111012-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. Acts upstream of or within cranial skeletal system development. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in head; optic tectum; and pectoral fin. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 46. Orthologous to human NDST1 (N-deacetylase and N-sulfotransferase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See ndst1a in Genome Data Viewer
Location:
chromosome: 14
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (2991347..3031810, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (2740230..2780693, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 Neighboring gene uncharacterized LOC137487558 Neighboring gene bicaudal C homolog 2 Neighboring gene si:dkey-201i24.3 Neighboring gene CD74 molecule, major histocompatibility complex, class II invariant chain a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables [heparan sulfate]-glucosamine N-sulfotransferase activity  
enables [heparan sulfate]-glucosamine N-sulfotransferase activity  
enables deacetylase activity  
enables deacetylase activity  
enables hydrolase activity  
enables sulfotransferase activity  
Component Evidence Code Pubs
is_active_in Golgi apparatus  
located_in Golgi apparatus  
located_in membrane  

General protein information

Preferred Names
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
Names
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1-like
NP_001311428.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324499.1NP_001311428.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

    Status: VALIDATED

    Source sequence(s)
    CU468924
    UniProtKB/TrEMBL
    A0A8M1P8G7, E7F0G2
    Related
    ENSDARP00000084646.4, ENSDART00000090213.6
    Conserved Domains (2) summary
    pfam00685
    Location:592839
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:27502
    HSNSD; heparan sulfate-N-deacetylase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    2991347..3031810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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