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cdh1.S cadherin 1, type 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 100337618, updated on 4-Jan-2025

Summary

Official Symbol
cdh1.S
Official Full Name
cadherin 1, type 1 S homeolog
Primary source
Xenbase:XB-GENE-6464305
Locus tag
XELAEV_18024918mg
See related
EnsemblRapid:ENSXLAG00005010043 AllianceGenome:Xenbase:XB-GENE-6464305
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
uvo; cdh1; cdhe; ecad; lcam; arc-1; cd324
Summary
Predicted to enable calcium ion binding activity. Predicted to act upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in several cellular components, including Golgi apparatus; adherens junction; and desmosome. Is expressed in dermal system and ectoderm. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); carcinoma (multiple); cervix uteri carcinoma in situ; and reproductive organ cancer (multiple). Orthologous to human CDH1 (cadherin 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See cdh1.S in Genome Data Viewer
Location:
chromosome: 4S
Exon count:
17
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4S NC_054378.1 (43274848..43311236, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4S NC_030731.1 (41881578..41917169, complement)

Chromosome 4S - NC_054378.1Genomic Context describing neighboring genes Neighboring gene chromosome transmission fidelity protein 8 homolog Neighboring gene UTP4 small subunit processome component S homeolog Neighboring gene hyaluronan synthase 3 S homeolog Neighboring gene cadherin 3 S homeolog Neighboring gene forkhead box C2 S homeolog

Genomic regions, transcripts, and products

Bibliography

Interactions

General gene information

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables calcium ion binding  
enables metal ion binding  
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in adherens junction  
located_in anchoring junction  
located_in cell junction  
located_in cytoplasm  
located_in desmosome  
located_in endosome  
located_in plasma membrane  

General protein information

Preferred Names
cadherin-1
Names
E-cadherin
cadherin 1, type 1, E-cadherin (epithelial)
epithelial cadherin
uvomorulin
xTCAD-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172232.1NP_001165703.1  cadherin-1 precursor

    See identical proteins and their annotated locations for NP_001165703.1

    Status: PROVISIONAL

    Source sequence(s)
    U04708
    UniProtKB/Swiss-Prot
    P30944, Q91709
    UniProtKB/TrEMBL
    A0A974D168
    Related
    ENSXLAP00005029564.1, ENSXLAT00005030310.1
    Conserved Domains (4) summary
    cd11304
    Location:260366
    Cadherin_repeat; Cadherin tandem repeat domain
    smart01055
    Location:30115
    Cadherin_pro; Cadherin prodomain like
    pfam01049
    Location:733868
    Cadherin_C; Cadherin cytoplasmic region
    cl09101
    Location:152252
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    43274848..43311236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018259321.2XP_018114810.1  cadherin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8J0V4G5, A0A974D168
    Related
    ENSXLAP00005029569.1, ENSXLAT00005030315.1
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