Fmn2 formin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Fmn2provided by RGD
Full Name: formin 2provided by RGD
Primary source: RGD:2322099
See related: Ensembl:ENSRNOG00000061764 AllianceGenome:RGD:2322099
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AABR07021812.1
Summary: Predicted to enable actin binding activity. Predicted to be involved in several processes, including cytoskeleton organization; meiotic nuclear division; and positive regulation of double-strand break repair. Predicted to act upstream of or within actin filament bundle assembly and meiotic chromosome movement towards spindle pole. Predicted to be located in several cellular components, including microvillus; nucleolus; and spindle. Predicted to colocalize with actin cytoskeleton. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human FMN2 (formin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 61.8) and Uterus (RPKM 3.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (88986863..89303789)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (86454256..86771437)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (92569256..92887302)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BF397101 (e-PCR)
- UniSTS:246110

BF388231 (e-PCR)
- UniSTS:244873

BF405930 (e-PCR)
- UniSTS:247977

stSG628095 (e-PCR)
- UniSTS:457443

D13Got77 (e-PCR)
- UniSTS:112371

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in establishment of meiotic spindle localization	ISO Inferred from Sequence Orthology more info
involved_in formin-nucleated actin cable assembly	ISO Inferred from Sequence Orthology more info
involved_in homologous chromosome movement towards spindle pole in meiosis I anaphase	ISO Inferred from Sequence Orthology more info
involved_in intracellular transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within meiotic chromosome movement towards spindle pole	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in oogenesis	ISO Inferred from Sequence Orthology more info
involved_in polar body extrusion after meiotic divisions	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in actin filament	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: formin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.