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Astn2 astrotactin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100361323, updated on 13-Apr-2024

Summary

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Official Symbol
Astn2provided by RGD
Official Full Name
astrotactin 2provided by RGD
Primary source
RGD:2320342
See related
Ensembl:ENSRNOG00000060105 AllianceGenome:RGD:2320342
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity and inositol 1,3,4,5 tetrakisphosphate binding activity. Predicted to act upstream of or within establishment of body hair planar orientation and negative regulation of protein localization to cell surface. Predicted to be located in cell pole and endosome. Predicted to be integral component of membrane. Orthologous to human ASTN2 (astrotactin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 111.6), Adrenal (RPKM 20.4) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Astn2 in Genome Data Viewer
Location:
5q24
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (83772988..84759439, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (78758142..79744021, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (81179614..82168528, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit d, mitochondrial-like Neighboring gene pappalysin Neighboring gene tripartite motif-containing 32 Neighboring gene RNA, U6 small nuclear 1015 Neighboring gene H2A.Z variant histone 2, pseudogene 2 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene toll-like receptor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Astn2, a novel member of the astrotactin gene family, regulates the trafficking of ASTN1 during glial-guided neuronal migration. Wilson PM, et al. J Neurosci, 2010 Jun 23. PMID 20573900, Free PMC Article
  2. Identification of Astrotactin2 as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles. Chang H, et al. PLoS Genet, 2015. PMID 26418459, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables inositol 1,3,4,5 tetrakisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within establishment of body hair planar orientation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron migration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell pole ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
astrotactin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271363.1 → NP_001258292.1  astrotactin-2

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A096MK06
    Related
    ENSRNOP00000075622.2, ENSRNOT00000084959.2
    Conserved Domains (3) summary
    smart00457
    Location:867 → 1050
    MACPF; membrane-attack complex / perforin
    cd00063
    Location:1081 → 1203
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam14670
    Location:718 → 765
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    83772988..84759439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287034.1 → XP_063143104.1  astrotactin-2 isoform X3

  2. XM_017593112.3 → XP_017448601.1  astrotactin-2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JYU3
    Related
    ENSRNOP00000070791.2

  3. XM_017593110.3 → XP_017448599.2  astrotactin-2 isoform X1

    Conserved Domains (5) summary
    smart00457
    Location:863 → 1046
    MACPF; membrane-attack complex / perforin
    cd00063
    Location:1077 → 1199
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam14670
    Location:714 → 761
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    pfam18411
    Location:1201 → 1293
    Annexin_like; Annexin-like domain
    pfam18577
    Location:1297 → 1343
    ASTN_2_hairpin; Astrotactin-2 C-terminal beta-hairpin domain

  4. XM_017593109.3 → XP_017448598.2  astrotactin-2 isoform X4

    Conserved Domains (2) summary
    smart00457
    Location:867 → 1050
    MACPF; membrane-attack complex / perforin
    pfam14670
    Location:718 → 765
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein Strain
Heading Accession and Version

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