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Galnt6 polypeptide N-acetylgalactosaminyltransferase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100361647, updated on 3-Apr-2024

Summary

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Official Symbol
Galnt6provided by RGD
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 6provided by RGD
Primary source
RGD:2319726
See related
Ensembl:ENSRNOG00000033059 AllianceGenome:RGD:2319726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Orthologous to human GALNT6 (polypeptide N-acetylgalactosaminyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 66.0), Thymus (RPKM 63.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q36
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (133668612..133715909, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (131789836..131828077, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (142322172..142364281, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene bridging integrator 2 Neighboring gene uncharacterized LOC134479578 Neighboring gene chymotrypsin like elastase 1 Neighboring gene solute carrier family 4 member 8 Neighboring gene uncharacterized LOC134479785

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy. Bennett EP, et al. J Biol Chem, 1999 Sep 3. PMID 10464263
  2. The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization. Argüeso P, et al. Invest Ophthalmol Vis Sci, 2003 Jan. PMID 12506059
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation via threonine ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 6
Names
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
NP_001165534.1
XP_006242357.1
XP_006242358.1
XP_008763873.1
XP_038934161.1
XP_063118905.1
XP_063118906.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172063.2 → NP_001165534.1  polypeptide N-acetylgalactosaminyltransferase 6

    See identical proteins and their annotated locations for NP_001165534.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    D4A864
    Conserved Domains (2) summary
    cd02510
    Location:180 → 485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497 → 619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    133668612..133715909 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262835.1 → XP_063118905.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

    UniProtKB/TrEMBL
    D4A864

  2. XM_006242296.5 → XP_006242358.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

    See identical proteins and their annotated locations for XP_006242358.1

    UniProtKB/TrEMBL
    D4A864
    Related
    ENSRNOP00000070003.1
    Conserved Domains (2) summary
    cd02510
    Location:180 → 485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497 → 619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  3. XM_039078233.2 → XP_038934161.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

    UniProtKB/TrEMBL
    D4A864
    Conserved Domains (2) summary
    cd02510
    Location:180 → 485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497 → 619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  4. XM_006242295.5 → XP_006242357.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

    See identical proteins and their annotated locations for XP_006242357.1

    UniProtKB/TrEMBL
    D4A864
    Conserved Domains (2) summary
    cd02510
    Location:180 → 485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497 → 619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  5. XM_008765651.4 → XP_008763873.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

    See identical proteins and their annotated locations for XP_008763873.1

    UniProtKB/TrEMBL
    D4A864
    Conserved Domains (2) summary
    cd02510
    Location:180 → 485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497 → 619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  6. XM_063262836.1 → XP_063118906.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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