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Usp37 ubiquitin specific peptidase 37 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100361658, updated on 13-Apr-2024

Summary

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Official Symbol
Usp37provided by RGD
Official Full Name
ubiquitin specific peptidase 37provided by RGD
Primary source
RGD:2319715
See related
Ensembl:ENSRNOG00000022720 AllianceGenome:RGD:2319715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cysteine-type endopeptidase activity; protein kinase binding activity; and thiol-dependent deubiquitinase. Predicted to be involved in G1/S transition of mitotic cell cycle; protein deubiquitination; and regulation of DNA replication. Predicted to be active in cytosol and nucleus. Orthologous to human USP37 (ubiquitin specific peptidase 37). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 132.7), Thymus (RPKM 107.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Usp37 in Genome Data Viewer
Location:
9q33
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (83467966..83567848, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76018863..76118732, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (81717626..81818421, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene CTD small phosphatase 1 Neighboring gene microRNA 26b Neighboring gene villin 1 Neighboring gene transfer RNA proline (anticodon AGG) 59 Neighboring gene CCR4-NOT transcription complex subunit 9 Neighboring gene phospholipase C, delta 4 Neighboring gene zinc finger protein 142 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication. Hernández-Pérez S, et al. Mol Oncol, 2016 Oct. PMID 27296872, Free PMC Article
  2. Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. Huang X, et al. Mol Cell, 2011 May 20. PMID 21596315
  3. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Quesada V, et al. Biochem Biophys Res Commun, 2004 Jan 30. PMID 14715245
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 37
Names
ubiquitin specific protease 37
NP_001414600.1
XP_006245354.1
XP_006245355.1
XP_006245356.1
XP_006245357.1
XP_006245358.1
XP_008765529.1
XP_063122570.1
XP_063122571.1
XP_063122572.1
XP_063122573.1
XP_063122574.1
XP_063122575.1
XP_063122576.1
XP_063122577.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427671.1 → NP_001414600.1  ubiquitin carboxyl-terminal hydrolase 37

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    D4ABE5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    83467966..83567848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266507.1 → XP_063122577.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X6

  2. XM_063266503.1 → XP_063122573.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X4

    UniProtKB/TrEMBL
    A0A8I6B2I8

  3. XM_063266501.1 → XP_063122571.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X2

  4. XM_008767307.4 → XP_008765529.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    See identical proteins and their annotated locations for XP_008765529.1

    UniProtKB/TrEMBL
    A0A8I6GH62, D4ABE5
    Conserved Domains (3) summary
    cd02257
    Location:342 → 603
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342 → 600
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

  5. XM_006245293.5 → XP_006245355.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    See identical proteins and their annotated locations for XP_006245355.1

    UniProtKB/TrEMBL
    A0A8I6GH62, D4ABE5
    Conserved Domains (3) summary
    cd02257
    Location:342 → 603
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342 → 600
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

  6. XM_063266500.1 → XP_063122570.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    UniProtKB/TrEMBL
    D4ABE5

  7. XM_063266506.1 → XP_063122576.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X6

  8. XM_063266505.1 → XP_063122575.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X5

  9. XM_063266502.1 → XP_063122572.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X3

  10. XM_006245295.5 → XP_006245357.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X2

    See identical proteins and their annotated locations for XP_006245357.1

    UniProtKB/TrEMBL
    A0A8I6GH62
    Conserved Domains (3) summary
    cd02257
    Location:342 → 603
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342 → 600
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

  11. XM_006245296.4 → XP_006245358.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X4

    See identical proteins and their annotated locations for XP_006245358.1

    UniProtKB/TrEMBL
    A0A8I6B2I8, A0A8I6GH62
    Related
    ENSRNOP00000095391.1
    Conserved Domains (3) summary
    cd02257
    Location:342 → 603
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342 → 600
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

  12. XM_006245292.5 → XP_006245354.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    See identical proteins and their annotated locations for XP_006245354.1

    UniProtKB/TrEMBL
    A0A8I6GH62, D4ABE5
    Related
    ENSRNOP00000033308.1
    Conserved Domains (3) summary
    cd02257
    Location:342 → 603
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342 → 600
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

  13. XM_063266504.1 → XP_063122574.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X4

    UniProtKB/TrEMBL
    A0A8I6B2I8

  14. XM_006245294.5 → XP_006245356.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    See identical proteins and their annotated locations for XP_006245356.1

    UniProtKB/TrEMBL
    A0A8I6GH62, D4ABE5
    Conserved Domains (3) summary
    cd02257
    Location:342 → 603
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342 → 600
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
Nucleotide Protein Strain
Heading Accession and Version

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