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Zfp42 zinc finger protein 42 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100361947, updated on 13-Apr-2024

Summary

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Symbol
Zfp42provided by RGD
Full Name
zinc finger protein 42provided by RGD
Primary source
RGD:2319133
See related
Ensembl:ENSRNOG00000067356 AllianceGenome:RGD:2319133
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zfp971
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in female gonad development; male gonad development; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of genetic imprinting; and spermatid development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-containing complex. Orthologous to human ZFP42 (ZFP42 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 46.5) and Brain (RPKM 9.6) See more
Orthologs
human mouse all
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Genomic context

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See Zfp42 in Genome Data Viewer
Location:
16q12.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (55568903..55577883)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (48836463..48845443)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (52016590..52026346)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor co-repressor 1, pseudogene 1 Neighboring gene high-mobility group box 1, pseudogene 28 Neighboring gene ribosomal protein L23,pseudogene 1 Neighboring gene small nuclear ribonucleoprotein polypeptide C, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rex1 (Zfp42) null mice show impaired testicular function, abnormal testis morphology, and aberrant gene expression. Rezende NC, et al. Dev Biol, 2011 Aug 15. PMID 21641340, Free PMC Article
  2. Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma. Raman JD, et al. Carcinogenesis, 2006 Mar. PMID 16344273
  3. Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cells. Xu J, et al. J Mol Biol, 2008 Mar 14. PMID 18237746, Free PMC Article
  4. Retroposition and evolution of the DNA-binding motifs of YY1, YY2 and REX1. Kim JD, et al. Nucleic Acids Res, 2007. PMID 17478514, Free PMC Article
  5. Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. Kristensen DM, et al. Hum Reprod, 2008 Apr. PMID 18281244

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in female gonad development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within genomic imprinting ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in male gonad development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatid development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 42 homolog
Names
zinc finger protein 971

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402569.1 → NP_001389498.1  zinc finger protein 42 homolog

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6ATC5, A6JPS8
    Related
    ENSRNOP00000096008.1, ENSRNOT00000099839.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    55568903..55577883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253172.5 → XP_006253234.1  zinc finger protein 42 homolog isoform X1

    See identical proteins and their annotated locations for XP_006253234.1

    UniProtKB/TrEMBL
    A0A8I6AIJ5, A0A8I6ATC5, A6JPS8
    Related
    ENSRNOP00000093057.1
    Conserved Domains (2) summary
    COG5048
    Location:215 → 290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:218 → 238
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_039094996.2 → XP_038950924.1  zinc finger protein 42 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIJ5, A0A8I6ATC5, A6JPS8
    Related
    ENSRNOP00000096850.1
    Conserved Domains (2) summary
    COG5048
    Location:215 → 290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:218 → 238
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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