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Mpv17l MPV17 mitochondrial inner membrane protein like [ Rattus norvegicus (Norway rat) ]

Gene ID: 100362572, updated on 13-Apr-2024

Summary

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Symbol
Mpv17lprovided by RGD
Full Name
MPV17 mitochondrial inner membrane protein likeprovided by RGD
Primary source
RGD:2324483
See related
Ensembl:ENSRNOG00000003285 AllianceGenome:RGD:2324483
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in negative regulation of hydrogen peroxide biosynthetic process; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; and reactive oxygen species metabolic process. Predicted to be located in peroxisome. Predicted to be active in mitochondrion. Orthologous to human MPV17L (MPV17 mitochondrial inner membrane protein like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 368.7), Liver (RPKM 85.9) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Mpv17l in Genome Data Viewer
Location:
10q11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (2495605..2532448, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (1988451..2025300, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (3321488..3359219)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein uL13-like Neighboring gene bMERB domain containing 1 Neighboring gene nuclear receptor coactivator 4, pseudogene 1 Neighboring gene pyridoxal-dependent decarboxylase domain containing 1 Neighboring gene uncharacterized LOC102552514 Neighboring gene N-terminal asparagine amidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes. Iida R, et al. Biochem Biophys Res Commun, 2006 Jun 9. PMID 16631601
  2. Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP. Iida R, et al. Free Radic Biol Med, 2012 Apr 15. PMID 22306510
  3. A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. Ghosh D, et al. J Am Chem Soc, 2010 Mar 24. PMID 20178365
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of hydrogen peroxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mpv17-like protein
Names
MPV17 mitochondrial membrane protein-like
Mpv17 transgene, kidney disease mutant-like (predicted)-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402078.1 → NP_001389007.1  mpv17-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6K4F3

  2. NM_001402079.1 → NP_001389008.1  mpv17-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    2495605..2532448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767468.4 → XP_008765690.1  mpv17-like protein isoform X3

    See identical proteins and their annotated locations for XP_008765690.1

    Conserved Domains (1) summary
    pfam04117
    Location:9 → 68
    Mpv17_PMP22; Mpv17 / PMP22 family

  2. XM_063268245.1 → XP_063124315.1  mpv17-like protein isoform X6

  3. XM_008767467.4 → XP_008765689.1  mpv17-like protein isoform X1

    See identical proteins and their annotated locations for XP_008765689.1

    UniProtKB/TrEMBL
    A6K4F2
    Conserved Domains (1) summary
    pfam04117
    Location:107 → 156
    Mpv17_PMP22; Mpv17 / PMP22 family

  4. XM_063268244.1 → XP_063124314.1  mpv17-like protein isoform X5

  5. XM_008767469.3 → XP_008765691.1  mpv17-like protein isoform X4

    See identical proteins and their annotated locations for XP_008765691.1

    Conserved Domains (1) summary
    pfam04117
    Location:3 → 62
    Mpv17_PMP22; Mpv17 / PMP22 family

  6. XM_063268243.1 → XP_063124313.1  mpv17-like protein isoform X2

RNA

  1. XR_010055116.1 RNA Sequence

  2. XR_010055114.1 RNA Sequence

  3. XR_010055115.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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