Txndc5 thioredoxin domain containing 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Txndc5provided by RGD
Official Full Name: thioredoxin domain containing 5provided by RGD
Primary source: RGD:2323973
See related: Ensembl:ENSRNOG00000013469 AllianceGenome:RGD:2323973
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein disulfide isomerase activity. Predicted to be involved in apoptotic cell clearance. Predicted to be located in endoplasmic reticulum lumen. Orthologous to human TXNDC5 (thioredoxin domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 763.2), Spleen (RPKM 476.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (26495467..26523608)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (26289880..26318025)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (26925828..26953981)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE115555 (e-PCR)
- UniSTS:248174

RH129157 (e-PCR)
- UniSTS:212465

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein disulfide isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein disulfide isomerase activity	ISO Inferred from Sequence Orthology more info
enables protein-disulfide reductase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thioredoxin domain-containing protein 5

Names: thioredoxin domain containing 5 (endoplasmic reticulum)

NP_001258259.1

EC 5.3.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271330.1 → NP_001258259.1 thioredoxin domain-containing protein 5 precursor

See identical proteins and their annotated locations for NP_001258259.1

Status: VALIDATED

Source sequence(s)

FM045749, FM067602, FM093163, JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I6GKN1, A6J7A3, D3ZZC1

Related

ENSRNOP00000018310.5, ENSRNOT00000018310.8

Conserved Domains (2) summary

cd03005
Location:176 → 276

PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...

TIGR01130
Location:52 → 417

ER_PDI_fam; protein disulfide isomerase, eukaryotic