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Snx21 sorting nexin family member 21 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100362940, updated on 30-Mar-2024

Summary

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Official Symbol
Snx21provided by RGD
Official Full Name
sorting nexin family member 21provided by RGD
Primary source
RGD:2323753
See related
Ensembl:ENSRNOG00000064429 AllianceGenome:RGD:2323753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in protein transport. Predicted to be located in early endosome membrane. Orthologous to human SNX21 (sorting nexin family member 21). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 83.1), Brain (RPKM 68.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q42
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (173941634..173951571)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (153522474..153532235)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (161252634..161261880)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2C Neighboring gene troponin C2, fast skeletal type Neighboring gene acyl-CoA thioesterase 8 Neighboring gene zinc finger, SWIM-type containing 3 Neighboring gene zinc finger, SWIM-type containing 1 Neighboring gene spermatogenesis associated 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure and Membrane Binding Properties of the Endosomal Tetratricopeptide Repeat (TPR) Domain-containing Sorting Nexins SNX20 and SNX21. Clairfeuille T, et al. J Biol Chem, 2015 Jun 5. PMID 25882846, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sorting nexin-21
Names
sorting nexin 21
sorting nexin 21-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399714.1 → NP_001386643.1  sorting nexin-21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5ZZC7
    Related
    ENSRNOP00000083481.1, ENSRNOT00000095491.1
    Conserved Domains (3) summary
    sd00006
    Location:234 → 258
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:234 → 303
    TPR_12; Tetratricopeptide repeat
    cl02563
    Location:121 → 232
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  2. NM_001399715.1 → NP_001386644.1  sorting nexin-21 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    173941634..173951571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282970.1 → XP_063139040.1  sorting nexin-21 isoform X3

  2. XM_063282969.1 → XP_063139039.1  sorting nexin-21 isoform X1

  3. XM_039106723.2 → XP_038962651.2  sorting nexin-21 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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