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Nt5c2 5'-nucleotidase, cytosolic II [ Rattus norvegicus (Norway rat) ]

Gene ID: 100363253, updated on 13-Apr-2024

Summary

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Official Symbol
Nt5c2provided by RGD
Official Full Name
5'-nucleotidase, cytosolic IIprovided by RGD
Primary source
RGD:2323387
See related
Ensembl:ENSRNOG00000020179 AllianceGenome:RGD:2323387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables 5'-nucleotidase activity. Involved in IMP metabolic process and adenosine metabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 45. Orthologous to human NT5C2 (5'-nucleotidase, cytosolic II). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 161.8), Adrenal (RPKM 113.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nt5c2 in Genome Data Viewer
Location:
1q54
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (255712797..255838285, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (245770993..245896925, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (266652966..266782935, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484091 Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 2 Neighboring gene uncharacterized LOC134484086 Neighboring gene transfer RNA arginine (anticodon UCU) 2 Neighboring gene internexin neuronal intermediate filament protein, alpha Neighboring gene polycomb group ring finger 6 Neighboring gene TATA-box binding protein associated factor 5 Neighboring gene ATP synthase membrane subunit K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Purification and some properties of cytosol 5'-nucleotidase from rat liver. Itoh R. Biochim Biophys Acta, 1981 Feb 13. PMID 6260203
  2. Differences in cytosolic and mitochondrial 5'-nucleotidase and deoxynucleoside kinase activities in Sprague-Dawley rat and CD-1 mouse tissues: implication for the toxicity of nucleoside analogs in animal models. Mirzaee S, et al. Toxicology, 2010 Jan 12. PMID 19913594
  3. Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition. Walldén K, et al. J Biol Chem, 2007 Jun 15. PMID 17405878
  4. High Km soluble 5'-nucleotidase from human placenta. Properties and allosteric regulation by IMP and ATP. Spychała J, et al. J Biol Chem, 1988 Dec 15. PMID 2848805
  5. Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation. Mackiewicz M, et al. J Neurochem, 2003 Apr. PMID 12675911

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-nucleotidase activity IEA
Inferred from Electronic Annotation
more info
  
enables 5'-nucleotidase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GMP 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GMP 5'-nucleotidase activity ISO
Inferred from Sequence Orthology
more info
  
enables IMP 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables IMP 5'-nucleotidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside phosphotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside phosphotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in GMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GMP catabolic process to guanine ISO
Inferred from Sequence Orthology
more info
  
involved_in GMP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in GMP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GMP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in IMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in IMP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in IMP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in IMP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in adenosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenosine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in allantoin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in amide catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dGMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dGMP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dGMP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cytosolic purine 5'-nucleotidase
Names
cytosolic nucleoside phosphotransferase 5'N
NP_001388640.1
XP_002728937.1
XP_038957357.1
XP_038957358.1
XP_038957359.1
XP_038957360.1
XP_063138838.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401711.1 → NP_001388640.1  cytosolic purine 5'-nucleotidase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    D3ZMY7
    UniProtKB/TrEMBL
    A6JHP1
    Related
    ENSRNOP00000027351.7, ENSRNOT00000027351.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    255712797..255838285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002728891.7 → XP_002728937.1  cytosolic purine 5'-nucleotidase isoform X2

    See identical proteins and their annotated locations for XP_002728937.1

    UniProtKB/TrEMBL
    A0A8I6A978, A0A8I6GLV2
    Related
    ENSRNOP00000096997.1
    Conserved Domains (1) summary
    pfam05761
    Location:69 → 514
    5_nucleotid; 5' nucleotidase family

  2. XM_063282768.1 → XP_063138838.1  cytosolic purine 5'-nucleotidase isoform X1

    UniProtKB/Swiss-Prot
    D3ZMY7
    UniProtKB/TrEMBL
    A6JHP1

  3. XM_039101430.2 → XP_038957358.1  cytosolic purine 5'-nucleotidase isoform X1

    UniProtKB/Swiss-Prot
    D3ZMY7
    UniProtKB/TrEMBL
    A0A8L2QH70, A6JHP1
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 488
    5_nucleotid; 5' nucleotidase family

  4. XM_039101429.2 → XP_038957357.1  cytosolic purine 5'-nucleotidase isoform X1

    UniProtKB/Swiss-Prot
    D3ZMY7
    UniProtKB/TrEMBL
    A0A8L2QH70, A6JHP1
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 488
    5_nucleotid; 5' nucleotidase family

  5. XM_039101431.2 → XP_038957359.1  cytosolic purine 5'-nucleotidase isoform X3

    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  6. XM_039101432.2 → XP_038957360.1  cytosolic purine 5'-nucleotidase isoform X3

    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZMY7.4 GenPept UniProtKB/Swiss-Prot:D3ZMY7

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