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Rnf11 ring finger protein 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100364162, updated on 3-Apr-2024

Summary

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Official Symbol
Rnf11provided by RGD
Official Full Name
ring finger protein 11provided by RGD
Primary source
RGD:2321596
See related
Ensembl:ENSRNOG00000057589 AllianceGenome:RGD:2321596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rnf11l1
Summary
Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to be involved in protein autoubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 484.8), Heart (RPKM 373.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q35
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (129441071..129471799, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (124212433..124243125, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (129091930..129113132, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351012 Neighboring gene calreticulin 4 Neighboring gene epidermal growth factor receptor pathway substrate 15 Neighboring gene tetratricopeptide repeat domain 39A Neighboring gene similar to human chromosome 1 open reading frame 185 Neighboring gene RNA, U4 small nuclear 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-κB signaling in dopaminergic cells. Pranski EL, et al. Neurobiol Dis, 2013 Jun. PMID 23318928, Free PMC Article
  2. Regulation of NF-κB by ubiquitination. Chen J, et al. Curr Opin Immunol, 2013 Feb. PMID 23312890, Free PMC Article
  3. Deubiquitinases in the regulation of NF-κB signaling. Harhaj EW, et al. Cell Res, 2011 Jan. PMID 21119682, Free PMC Article
  4. Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients. Murakawa M, et al. J Med Virol, 2017 Jul. PMID 28036111
  5. An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein. Li H, et al. Oncogene, 2004 Mar 11. PMID 14755250

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. our findings demonstrate that RNF11 in neurons can modulate susceptibility to 6-OHDA toxicity through NF-kappaB mediated responses
    Title: RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-κB signaling in dopaminergic cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RING finger protein 11
Names
ring finger protein 1
ring finger protein 11-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271224.1 → NP_001258153.1  RING finger protein 11

    See identical proteins and their annotated locations for NP_001258153.1

    Status: VALIDATED

    Source sequence(s)
    BC088292
    UniProtKB/TrEMBL
    A0A0G2JZP9, A6JYZ1
    Related
    ENSRNOP00000071133.2, ENSRNOT00000080048.2
    Conserved Domains (1) summary
    cd16468
    Location:98 → 140
    RING-H2_RNF11; RING finger, H2 subclass, found in RING finger protein 11 (RNF11) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    129441071..129471799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287042.1 → XP_063143112.1  RING finger protein 11 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JZP9, A6JYZ1

  2. XM_063287040.1 → XP_063143110.1  RING finger protein 11 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JZP9, A6JYZ1

  3. XM_039109108.2 → XP_038965036.1  RING finger protein 11 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JZP9, A6JYZ1
    Conserved Domains (1) summary
    cd16468
    Location:98 → 140
    RING-H2_RNF11; RING finger, H2 subclass, found in RING finger protein 11 (RNF11) and similar proteins

  4. XM_063287041.1 → XP_063143111.1  RING finger protein 11 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JZP9, A6JYZ1

  5. XM_063287039.1 → XP_063143109.1  RING finger protein 11 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JZP9, A6JYZ1
Nucleotide Protein Strain
Heading Accession and Version

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