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MTRNR2L1 MT-RNR2 like 1 (pseudogene) [ Homo sapiens (human) ]

Gene ID: 100462977, updated on 8-Mar-2024

Summary

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Official Symbol
MTRNR2L1provided by HGNC
Official Full Name
MT-RNR2 like 1 (pseudogene)provided by HGNC
Primary source
HGNC:HGNC:37155
See related
MIM:616985; AllianceGenome:HGNC:37155
Gene type
pseudo
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HN1
Summary
Predicted to enable receptor antagonist activity. Predicted to be involved in negative regulation of execution phase of apoptosis. Predicted to be located in cytoplasm and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: It is unclear if this is a transcribed protein-coding gene, or if it is a nuclear pseudogene of the mitochondrial MT-RNR2 gene. [16 Mar 2015]
Orthologs
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Genomic context

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See MTRNR2L1 in Genome Data Viewer
Location:
17p11.2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (22523415..22524663)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (23211621..23212869)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (22022741..22023989)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MT-ND6 pseudogene 35 Neighboring gene MT-CYB pseudogene 13 Neighboring gene MT-ND1 pseudogene 15 Neighboring gene MT-ND2 pseudogene 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Roles of humanin and derivatives on the pathology of neurodegenerative diseases and cognition. Thiankhaw K, et al. Biochim Biophys Acta Gen Subj, 2022 Apr. PMID 35104624
  2. Assay Development and Measurement of the Aging Biomarker Humanin. Miller B, et al. Methods Mol Biol, 2020. PMID 32410037
  3. Follicular fluid humanin concentration is related to ovarian reserve markers and clinical pregnancy after IVF-ICSI: a pilot study. Rao M, et al. Reprod Biomed Online, 2019 Jan. PMID 30503199
  4. The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. Sreekumar PG, et al. Invest Ophthalmol Vis Sci, 2016 Mar. PMID 26990160, Free PMC Article
  5. [Humanin and its derivatives as peptides with potential antiapoptotic and confirmed neuroprotective activities]. Zapała B, et al. Przegl Lek, 2011. PMID 22010475

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Roles of humanin and derivatives on the pathology of neurodegenerative diseases and cognition.
    Title: Roles of humanin and derivatives on the pathology of neurodegenerative diseases and cognition.
  2. Assay Development and Measurement of the Aging Biomarker Humanin.
    Title: Assay Development and Measurement of the Aging Biomarker Humanin.
  3. Humanin concentration in the follicular fluid was positively associated with ovarian reserve and clinical pregnancy rate.
    Title: Follicular fluid humanin concentration is related to ovarian reserve markers and clinical pregnancy after IVF-ICSI: a pilot study.
  4. Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction
    Title: Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction.
  5. Humanin protected RPE cells against oxidative stress-induced cell death and restored mitochondrial function.
    Title: The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction.
  6. Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-beta.
    Title: Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-β.
  7. Data suggest that humanin (the first small peptide of a putative set of mitochondrial derived peptides) exhibits strong cytoprotective actions against various stress and disease models.
    Title: Humanin: a harbinger of mitochondrial-derived peptides?
  8. findings implied that HN protects cortical neurons from I/R injury by the increased SOD activity and that the protective effect of HN on neurons against I/R is concentration-dependent
    Title: Humanin protects cortical neurons from ischemia and reperfusion injury by the increased activity of superoxide dismutase.
  9. The in vivo studies suggest that humanin may protect against cognitive impairment, also due to ischemia/reperfusion injury.[review]
    Title: [Humanin and its derivatives as peptides with potential antiapoptotic and confirmed neuroprotective activities].
  10. Immunolocalization of humanin in human sperm and testis.
    Title: Immunolocalization of humanin in human sperm and testis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Other Names

  • MT-RNR2 pseudogene 1
  • humanin-like 1
  • humanin-like protein 1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_077217.1 

    Range
    101..1349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    22523415..22524663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    23211621..23212869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001190452.2: Suppressed sequence

    Description
    NM_001190452.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CJ68.1 GenPept UniProtKB/Swiss-Prot:P0CJ68

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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