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Rpl5 ribosomal protein L5 [ Mus musculus (house mouse) ]

Gene ID: 100503670, updated on 9-May-2024

Summary

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Official Symbol
Rpl5provided by MGI
Official Full Name
ribosomal protein L5provided by MGI
Primary source
MGI:MGI:102854
See related
Ensembl:ENSMUSG00000058558 AllianceGenome:MGI:102854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ska23; Skax23; U21RNA; Ska<m23Jus>
Summary
Predicted to enable RNA binding activity; ubiquitin ligase inhibitor activity; and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in several processes, including positive regulation of aminoacyl-tRNA ligase activity; regulation of cellular protein metabolic process; and ribosome biogenesis. Located in synapse. Is expressed in several structures, including central nervous system; gonad; intestine; sensory organ; and spleen. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 6; T-cell acute lymphoblastic leukemia; and glioblastoma. Orthologous to human RPL5 (ribosomal protein L5). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: In NCBI's Build 37.2 annotation of the reference assembly, Rpl5, which was represented by GeneID:19983, was incorrectly annotated as an intronless gene on chromosome 7. It has now been determined that Rpl5 is a multi-exon gene on chromosome 5. Therefore, GeneID:19983 has been replaced by GeneID:100503670 to restore the correct chromosome 5 location. The chromosome 7 location represents an Rpl5 pseudogene, which is now represented by GeneID:100043295. [17 Jun 2014]
Expression
Broad expression in CNS E11.5 (RPKM 297.0), placenta adult (RPKM 283.2) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108048388..108056871)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (107900508..107909005)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ecotropic viral integration site 5 Neighboring gene STARR-seq mESC enhancer starr_13893 Neighboring gene ubiquitin-conjugating enzyme E2D 2B Neighboring gene predicted gene, 42149 Neighboring gene STARR-positive B cell enhancer ABC_E9017 Neighboring gene STARR-positive B cell enhancer ABC_E4774 Neighboring gene small nucleolar RNA, C/D box 21 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:108355724-108355877 Neighboring gene predicted gene, 22270 Neighboring gene predicted gene, 26387 Neighboring gene divergent protein kinase domain 1A Neighboring gene STARR-positive B cell enhancer ABC_E8068 Neighboring gene STARR-positive B cell enhancer ABC_E10338 Neighboring gene STARR-positive B cell enhancer mm9_chr5:108408844-108409144 Neighboring gene STARR-positive B cell enhancer ABC_E6359 Neighboring gene predicted gene, 42150 Neighboring gene STARR-seq mESC enhancer starr_13899 Neighboring gene ribosomal protein S19, pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A new murine Rpl5 (uL18) mutation provides a unique model of variably penetrant Diamond-Blackfan anemia. Yu L, et al. Blood Adv, 2021 Oct 26. PMID 34464976, Free PMC Article
  2. Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice. Kazerounian S, et al. J Cancer, 2016. PMID 26722357, Free PMC Article
  3. p53-Independent cell cycle and erythroid differentiation defects in murine embryonic stem cells haploinsufficient for Diamond Blackfan anemia-proteins: RPS19 versus RPL5. Singh SA, et al. PLoS One, 2014. PMID 24558476, Free PMC Article
  4. Transcripts from opposite strands of gamma satellite DNA are differentially expressed during mouse development. Rudert F, et al. Mamm Genome, 1995 Feb. PMID 7767009
  5. Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53. Bywater MJ, et al. Cancer Cell, 2012 Jul 10. PMID 22789538, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A new murine Rpl5 (uL18) mutation provides a unique model of variably penetrant Diamond-Blackfan anemia.
    Title: A new murine Rpl5 (uL18) mutation provides a unique model of variably penetrant Diamond-Blackfan anemia.
  2. there is a fine tuned balance in the interaction of ribosomal proteins with the MDM2/p53 axis which is important in normal hematopoiesis.
    Title: Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in Erythropoiesis.
  3. Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition.
    Title: Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition.
  4. There was a significant delay in the G2/M phase in Rpl5 mutant cells, unaffected by p53 knockdown.
    Title: p53-Independent cell cycle and erythroid differentiation defects in murine embryonic stem cells haploinsufficient for Diamond Blackfan anemia-proteins: RPS19 versus RPL5.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC25420, MGC101934, MGC102309, MGC117998

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5S rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5S rRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 5'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin ligase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of protein neddylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal large subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein uL18
Names
60S ribosomal protein L5
NP_058676.1
XP_006534747.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016980.2 → NP_058676.1  large ribosomal subunit protein uL18

    See identical proteins and their annotated locations for NP_058676.1

    Status: VALIDATED

    Source sequence(s)
    BC083318, CD774263, CJ073701, CV561106
    Consensus CDS
    CCDS39199.1
    UniProtKB/Swiss-Prot
    P47962, Q9CR19
    UniProtKB/TrEMBL
    Q3U850, Q58EU6
    Related
    ENSMUSP00000080854.7, ENSMUST00000082223.13
    Conserved Domains (1) summary
    PTZ00069
    Location:1 → 295
    PTZ00069; 60S ribosomal protein L5; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    108048388..108056871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534684.4 → XP_006534747.1  large ribosomal subunit protein uL18 isoform X1

    See identical proteins and their annotated locations for XP_006534747.1

    UniProtKB/TrEMBL
    Q3TKR5, Q3U850
    Conserved Domains (1) summary
    PTZ00069
    Location:1 → 294
    PTZ00069; 60S ribosomal protein L5; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47962.3 GenPept UniProtKB/Swiss-Prot:P47962

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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