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Acp4 acid phosphatase 4 [ Mus musculus (house mouse) ]

Gene ID: 100503991, updated on 11-Apr-2024

Summary

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Official Symbol
Acp4provided by MGI
Official Full Name
acid phosphatase 4provided by MGI
Primary source
MGI:MGI:3644563
See related
Ensembl:ENSMUSG00000012777 AllianceGenome:MGI:3644563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acpt; Gm1432; EG546967
Summary
Predicted to enable acid phosphatase activity; protein tyrosine phosphatase activity; and receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including negative regulation of ERBB4 signaling pathway; negative regulation of cellular protein metabolic process; and regulation of neuronal synaptic plasticity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in lysosome and postsynaptic membrane. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1J. Orthologous to human ACP4 (acid phosphatase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 27.8), testis adult (RPKM 10.1) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 28.77 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43901427..43910814, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44252003..44261390, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2410002F23 gene Neighboring gene small nucleolar RNA, C/D box 88A Neighboring gene predicted gene, 23991 Neighboring gene STARR-positive B cell enhancer ABC_E2233 Neighboring gene predicted gene 15517 Neighboring gene predicted gene, 18905

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Testicular acid phosphatase induces odontoblast differentiation and mineralization. Choi H, et al. Cell Tissue Res, 2016 Apr. PMID 26547858
  2. Enamel defects in Acp4(R110C/R110C) mice and human ACP4 mutations. Liang T, et al. Sci Rep, 2022 Oct 1. PMID 36183038, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in lysosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of ERBB4 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of ERBB4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in odontogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuronal synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
testicular acid phosphatase
Names
acid phosphatase, testicular
NP_001181963.1
NP_001406344.1
XP_006540594.1
XP_011249074.2
XP_017177390.1
XP_017177391.1
XP_030097791.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195034.1 → NP_001181963.1  testicular acid phosphatase isoform 1 precursor

    Status: PROVISIONAL

    Source sequence(s)
    AC152939
    Consensus CDS
    CCDS57546.1
    UniProtKB/Swiss-Prot
    D3YTS9
    UniProtKB/TrEMBL
    F6WRF1
    Related
    ENSMUSP00000112922.3, ENSMUST00000118216.8
    Conserved Domains (1) summary
    cd07061
    Location:31 → 315
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

  2. NM_001419415.1 → NP_001406344.1  testicular acid phosphatase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC152939

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    43901427..43910814 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321901.2 → XP_017177390.1  testicular acid phosphatase isoform X2

    UniProtKB/TrEMBL
    D3YZU0
    Conserved Domains (1) summary
    cd07061
    Location:32 → 310
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

  2. XM_006540531.4 → XP_006540594.1  testicular acid phosphatase isoform X2

    UniProtKB/TrEMBL
    D3YZU0
    Conserved Domains (1) summary
    cd07061
    Location:32 → 310
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

  3. XM_017321902.3 → XP_017177391.1  testicular acid phosphatase isoform X3

    UniProtKB/TrEMBL
    D3YZU0
    Related
    ENSMUSP00000103578.2, ENSMUST00000107945.8
    Conserved Domains (1) summary
    cd07061
    Location:23 → 301
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

  4. XM_030241931.2 → XP_030097791.1  testicular acid phosphatase isoform X5

    Conserved Domains (1) summary
    cd07061
    Location:54 → 333
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

  5. XM_011250772.3 → XP_011249074.2  testicular acid phosphatase isoform X4

    UniProtKB/TrEMBL
    F6WRF1
    Conserved Domains (1) summary
    cd07061
    Location:54 → 333
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

RNA

  1. XR_003946367.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3YTS9.2 GenPept UniProtKB/Swiss-Prot:D3YTS9

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