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Snord116 small nucleolar RNA, C/D box 116 cluster [ Mus musculus (house mouse) ]

Gene ID: 100616072, updated on 9-May-2024

Summary

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Official Symbol
Snord116provided by MGI
Official Full Name
small nucleolar RNA, C/D box 116 clusterprovided by MGI
Primary source
MGI:MGI:1891407
Gene type
other
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pwcr1; MBII-85
Annotation information
not in current annotation release
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Genomic context

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Location:
7 C; 7

Bibliography

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Related articles in PubMed

  1. Comparison of mouse models reveals a molecular distinction between psychotic illness in PWS and schizophrenia. Zahova SK, et al. Transl Psychiatry, 2021 Aug 20. PMID 34417445, Free PMC Article
  2. Loss of Snord116 impacts lateral hypothalamus, sleep, and food-related behaviors. Pace M, et al. JCI Insight, 2020 Jun 18. PMID 32365348, Free PMC Article
  3. Ectopic expression of Snord115 in choroid plexus interferes with editing but not splicing of 5-Ht2c receptor pre-mRNA in mice. Raabe CA, et al. Sci Rep, 2019 Mar 12. PMID 30862860, Free PMC Article
  4. Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex. Coulson RL, et al. Nat Commun, 2018 Apr 24. PMID 29691382, Free PMC Article
  5. Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome. Polex-Wolf J, et al. J Clin Invest, 2018 Mar 1. PMID 29376887, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Snord116 Post-transcriptionally Increases Nhlh2 mRNA Stability: Implications for Human Prader-Willi Syndrome.
    Title: Snord116 Post-transcriptionally Increases Nhlh2 mRNA Stability: Implications for Human Prader-Willi Syndrome.
  2. Loss of Snord116 alters cortical neuronal activity in mice: a preclinical investigation of Prader-Willi syndrome.
    Title: Loss of Snord116 alters cortical neuronal activity in mice: a preclinical investigation of Prader-Willi syndrome.
  3. Loss of Snord116 impacts lateral hypothalamus, sleep, and food-related behaviors.
    Title: Loss of Snord116 impacts lateral hypothalamus, sleep, and food-related behaviors.
  4. Knockdown of Rbfox3, encoding neuron-specific splicing factor neuronal nuclei (NeuN) in Snord116+/--derived neurons, reduced splicing of the transgene in neurons... these results demonstrate that exogenous expression and neuron-specific splicing of the Snord116 locus are insufficient to rescue the genetic deficiency of Snord116 paternal deletion
    Title: Prader-Willi locus Snord116 RNA processing requires an active endogenous allele and neuron-specific splicing by Rbfox3/NeuN.
  5. A major genetic effect on rhythmic methylation in a mouse Snord116 deletion model of the imprinted disorder Prader-Willi syndrome.
    Title: Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex.
  6. Data indicate that the metabolic symptoms of Prader-Willi syndrome develop gradually and the Snord116 gene plays a critical role during this process.
    Title: Hypothalamus Specific Re-Introduction of SNORD116 into Otherwise Snord116 Deficient Mice Increased Energy Expenditure.
  7. Our study highlights that the function of Snord116 in the hypothalamus may be to enhance energy expenditure, likely via the NPY system, and also indicates that Snord116 function in mice is strongly dependent on environmental conditions such as cold exposure.
    Title: Ambient temperature modulates the effects of the Prader-Willi syndrome candidate gene Snord116 on energy homeostasis.
  8. snord116 RNA mutants have a bilateral reduction of the gray matter volume in the ventral hippocampus and in the septum areas, which are pivotal structures for maintaining theta rhythms throughout the brain
    Title: Deletion of the Snord116/SNORD116 Alters Sleep in Mice and Patients with Prader-Willi Syndrome.
  9. Lack of the Snord116 gene cluster in mice contributes to the development of a subset of Prader-Willi syndrome phenotypes seen in humans.
    Title: Snord116 is critical in the regulation of food intake and body weight.
  10. Snord116 deficiency mouse model exhibits particular endophenotypes with some relevance to Prader-Willi syndrome
    Title: Behavioural characteristics of the Prader-Willi syndrome related biallelic Snord116 mouse model.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

General gene information

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Markers

Other Names

  • Prader-Willi chromosome region 1 homolog
  • snoRNA MBII-85
Nucleotide Protein
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Gene LinkOut

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