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MIR4724 microRNA 4724 [ Homo sapiens (human) ]

Gene ID: 100616248, updated on 10-Oct-2023

Summary

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Official Symbol
MIR4724provided by HGNC
Official Full Name
microRNA 4724provided by HGNC
Primary source
HGNC:HGNC:41590
See related
Ensembl:ENSG00000284424 miRBase:MI0017361; AllianceGenome:HGNC:41590
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mir-4724
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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Location:
17q11.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (31534883..31534971)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (32480645..32480733)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (29861901..29861989)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RAB11 family interacting protein 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29794364-29795058 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:29796711-29797212 Neighboring gene RNA, 7SL, cytoplasmic 79, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:29803345-29804161 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29825931-29826892 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29826893-29827852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12013 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29836658-29837448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:29850121-29850755 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29851414-29852028 Neighboring gene Sharpr-MPRA regulatory region 11348 Neighboring gene RNA, 7SL, cytoplasmic 45, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12015 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12016 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8412 Neighboring gene tRNA-Thr (anticodon CGT) 4-1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:29884070-29884694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29886028-29886818 Neighboring gene microRNA 193a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. Persson H, et al. Cancer Res, 2011 Jan 1. PMID 21199797
  2. miRBase: integrating microRNA annotation and deep-sequencing data. Kozomara A, et al. Nucleic Acids Res, 2011 Jan. PMID 21037258, Free PMC Article
  3. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • hsa-mir-4724

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_039877.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC003101
    Related
    ENST00000579485.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    31534883..31534971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    32480645..32480733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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