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Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase [ Cricetulus griseus (Chinese hamster) ]

Gene ID: 100756363, updated on 8-Mar-2024

Summary

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Gene symbol
Hmgcr
Gene description
3-hydroxy-3-methylglutaryl-CoA reductase
Locus tag
I79_015809
See related
Ensembl:ENSCGRG00015009730
Gene type
protein coding
RefSeq status
MODEL
Organism
Cricetulus griseus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
20
Annotation release Status Assembly Chr Location
104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003614466.1 (548036..571934)
104 current CriGri-PICRH-1.0 (GCF_003668045.3) 2 NC_048595.1 (315334995..315359225, complement)

NW_003614466.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA-binding protein-like Neighboring gene ankyrin repeat domain 31 Neighboring gene ceramide transporter 1 Neighboring gene DNA polymerase kappa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum. Chin DJ, et al. Nature, 1984 Apr 12-18. PMID 6546784
  2. HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions. Reynolds GA, et al. Cell, 1984 Aug. PMID 6088070
  3. Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum. Liscum L, et al. J Biol Chem, 1985 Jan 10. PMID 3965461
  4. Prediction of transcribed PIWI-interacting RNAs from CHO RNAseq data. Gerstl MP, et al. J Biotechnol, 2013 Jun 20. PMID 23639388
  5. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Becker J, et al. J Biotechnol, 2011 Dec 10. PMID 21945585

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in coenzyme A metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Names
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
HMG-CoA reductase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

  1. NW_003614466.1 Reference CriGri_1.0 Primary Assembly

    Range
    548036..571934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027440475.2 → XP_027296276.1  3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform X1

    UniProtKB/TrEMBL
    A0A9J7JFG0, G3HXP6

Alternate CriGri-PICRH-1.0

Genomic

  1. NC_048595.1 Alternate CriGri-PICRH-1.0

    Range
    315334995..315359225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027401682.2 → XP_027257483.1  3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform X2

    UniProtKB/Swiss-Prot
    P00347
    UniProtKB/TrEMBL
    A0A9J7FHB8, G3HXP6
    Related
    ENSCGRP00015046193.1, ENSCGRT00015065824.1

  2. XM_027401680.2 → XP_027257481.1  3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform X1

    UniProtKB/TrEMBL
    A0A9J7JFG0, G3HXP6
    Related
    ENSCGRP00015047354.1, ENSCGRT00015047688.1

  3. XM_027401681.2 → XP_027257482.1  3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform X2

    UniProtKB/Swiss-Prot
    P00347
    UniProtKB/TrEMBL
    A0A9J7FHB8, G3HXP6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00347.1 GenPept UniProtKB/Swiss-Prot:P00347

Gene LinkOut

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