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Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase [ Cricetulus griseus (Chinese hamster) ]

Gene ID: 100763416, updated on 8-Mar-2024

Summary

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Gene symbol
Mtr
Gene description
5-methyltetrahydrofolate-homocysteine methyltransferase
See related
Ensembl:ENSCGRG00015012510
Gene type
protein coding
RefSeq status
MODEL
Organism
Cricetulus griseus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
35
Annotation release Status Assembly Chr Location
104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003614408.1 (214021..310103, complement)
104 current CriGri-PICRH-1.0 (GCF_003668045.3) 3 NC_048596.1 (236170105..236266657, complement)

NW_003614408.1Genomic Context describing neighboring genes Neighboring gene actinin alpha 2 Neighboring gene 40S ribosomal protein S24-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Becker J, et al. J Biotechnol, 2011 Dec 10. PMID 21945585

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cobalamin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methionine synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in pteridine-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
methionine synthase
Names
Methionine synthase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

  1. NW_003614408.1 Reference CriGri_1.0 Primary Assembly

    Range
    214021..310103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007648175.4 → XP_007646365.1  methionine synthase isoform X1

    See identical proteins and their annotated locations for XP_007646365.1

    UniProtKB/TrEMBL
    G3HWD4
    Conserved Domains (5) summary
    COG0646
    Location:8 → 328
    MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
    PRK09490
    Location:1 → 1249
    metH; B12-dependent methionine synthase; Provisional
    cd00740
    Location:359 → 615
    MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
    cd02069
    Location:659 → 885
    methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
    pfam02965
    Location:954 → 1234
    Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain

  2. XM_007648176.3 → XP_007646366.1  methionine synthase isoform X2

    UniProtKB/TrEMBL
    A0A061IBT7, A0A9J7JM81
    Conserved Domains (5) summary
    COG1410
    Location:173 → 1061
    MetH2; Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]
    cd00740
    Location:202 → 458
    MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
    cd02069
    Location:502 → 728
    methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
    pfam02965
    Location:797 → 1077
    Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain
    cl22882
    Location:33 → 171
    S-methyl_trans; Homocysteine S-methyltransferase

RNA

  1. XR_004774525.1 RNA Sequence

Alternate CriGri-PICRH-1.0

Genomic

  1. NC_048596.1 Alternate CriGri-PICRH-1.0

    Range
    236170105..236266657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027409452.2 → XP_027265253.1  methionine synthase isoform X1

    UniProtKB/TrEMBL
    G3HWD4
    Related
    ENSCGRP00015016338.2, ENSCGRT00015020059.2

  2. XM_027409453.2 → XP_027265254.1  methionine synthase isoform X2

    UniProtKB/TrEMBL
    A0A061IBT7, A0A9J7JM81

RNA

  1. XR_004769356.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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