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Duox1 dual oxidase 1 [ Cricetulus griseus (Chinese hamster) ]

Gene ID: 100774391, updated on 8-Mar-2024

Summary

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Gene symbol
Duox1
Gene description
dual oxidase 1
See related
Ensembl:ENSCGRG00015018623
Gene type
protein coding
RefSeq status
MODEL
Organism
Cricetulus griseus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
28
Annotation release Status Assembly Chr Location
104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003614086.1 (1204796..1232599, complement)
104 current CriGri-PICRH-1.0 (GCF_003668045.3) 6 NC_048599.1 (56081908..56114197, complement)

NW_003614086.1Genomic Context describing neighboring genes Neighboring gene transfer RNA histidin (anticodon GUG) Neighboring gene Src homology 2 domain containing F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables superoxide-generating NAD(P)H oxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in superoxide anion generation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of NADPH oxidase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dual oxidase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

  1. NW_003614086.1 Reference CriGri_1.0 Primary Assembly

    Range
    1204796..1232599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003504789.5 → XP_003504837.1  dual oxidase 1 isoform X1

    Conserved Domains (6) summary
    cd06186
    Location:1044 → 1318
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd00051
    Location:587 → 648
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl14561
    Location:1 → 358
    An_peroxidase_like; Animal heme peroxidases and related proteins
    pfam01794
    Location:858 → 1002
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03098
    Location:10 → 313
    An_peroxidase; Animal haem peroxidase
    pfam13499
    Location:587 → 647
    EF-hand_7; EF-hand domain pair

Alternate CriGri-PICRH-1.0

Genomic

  1. NC_048599.1 Alternate CriGri-PICRH-1.0

    Range
    56081908..56114197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027421992.2 → XP_027277793.1  dual oxidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C2MSP9
    Related
    ENSCGRP00015024564.1, ENSCGRT00015030139.2
Nucleotide Protein Strain
Heading Accession and Version

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