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Xirp1 xin actin-binding repeat containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100910104, updated on 19-May-2024

Summary

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Official Symbol
Xirp1provided by RGD
Official Full Name
xin actin-binding repeat containing 1provided by RGD
Primary source
RGD:1304776
See related
Ensembl:ENSRNOG00000037085 AllianceGenome:RGD:1304776
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cmya1
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and negative regulation of protein binding activity. Predicted to act upstream of or within several processes, including Notch signaling pathway; muscle cell development; and negative regulation of cell population proliferation. Predicted to be located in adherens junction and fascia adherens. Predicted to colocalize with focal adhesion and stress fiber. Orthologous to human XIRP1 (xin actin binding repeat containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 387.1), Heart (RPKM 380.8) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Xirp1 in Genome Data Viewer
Location:
8q32
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (128625111..128635011, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (119744778..119757547, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (128694809..128712092, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene cysteine and serine rich nuclear protein 1 Neighboring gene uncharacterized LOC108351801 Neighboring gene uncharacterized LOC120094294 Neighboring gene uncharacterized LOC134480114 Neighboring gene C-X3-C motif chemokine receptor 1 Neighboring gene C-C motif chemokine receptor 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure, Expression, and Function of a Novel Intercalated Disc Protein, Xin. Jung-Ching Lin J, et al. J Med Sci, 2005 Oct. PMID 16708114, Free PMC Article
  2. An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs. Holt I, et al. BMC Mol Cell Biol, 2020 Dec 1. PMID 33261556, Free PMC Article
  3. Xin repeats define a novel actin-binding motif. Pacholsky D, et al. J Cell Sci, 2004 Oct 15. PMID 15454575
  4. Requirement of a novel gene, Xin, in cardiac morphogenesis. Wang DZ, et al. Development, 1999 Mar. PMID 10021346
  5. Xin, an actin binding protein, is expressed within muscle satellite cells and newly regenerated skeletal muscle fibers. Hawke TJ, et al. Am J Physiol Cell Physiol, 2007 Nov. PMID 17855775

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs.
    Title: An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sarcomere organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in fascia adherens ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
xin actin-binding repeat containing 1; xin actin-binding repeat-containing protein 1
Names
cardiomyopathy associated 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430574.1 → NP_001417503.1  xin actin-binding repeat containing 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  2. NM_001430575.1 → NP_001417504.1  xin actin-binding repeat containing 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  3. NM_001430576.1 → NP_001417505.1  xin actin-binding repeat containing 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  4. NM_001430577.1 → NP_001417506.1  xin actin-binding repeat containing 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  5. NM_001430578.1 → NP_001417507.1  xin actin-binding repeat containing 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  6. NM_001430579.1 → NP_001417508.1  xin actin-binding repeat containing 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    128625111..128635011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244155.5 → XP_006244217.1  xin actin-binding repeat-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    D4ABA9
    Related
    ENSRNOP00000052739.4
    Conserved Domains (1) summary
    pfam08043
    Location:549 → 562
    Xin; Xin repeat

  2. XM_006244151.5 → XP_006244213.1  xin actin-binding repeat-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YBK9, A6I3Y7
    Related
    ENSRNOP00000091019.1
    Conserved Domains (2) summary
    PHA03247
    Location:902 → 1293
    PHA03247; large tegument protein UL36; Provisional
    pfam08043
    Location:510 → 525
    Xin; Xin repeat

  3. XM_008766701.4 → XP_008764923.1  xin actin-binding repeat-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_008764923.1

    UniProtKB/TrEMBL
    A0A8I5YBK9, A6I3Y7
    Conserved Domains (2) summary
    PHA03247
    Location:902 → 1293
    PHA03247; large tegument protein UL36; Provisional
    pfam08043
    Location:510 → 525
    Xin; Xin repeat

  4. XM_063266351.1 → XP_063122421.1  xin actin-binding repeat-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    D4ABA9

  5. XM_017596154.3 → XP_017451643.1  xin actin-binding repeat-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YBK9, A6I3Y7
    Related
    ENSRNOP00000077004.1
    Conserved Domains (2) summary
    PHA03247
    Location:902 → 1293
    PHA03247; large tegument protein UL36; Provisional
    pfam08043
    Location:510 → 525
    Xin; Xin repeat

  6. XM_063266352.1 → XP_063122422.1  xin actin-binding repeat-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    D4ABA9

  7. XM_039082728.2 → XP_038938656.1  xin actin-binding repeat-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YBK9, A6I3Y7
    Conserved Domains (2) summary
    PHA03247
    Location:902 → 1293
    PHA03247; large tegument protein UL36; Provisional
    pfam08043
    Location:510 → 525
    Xin; Xin repeat
Nucleotide Protein Strain
Heading Accession and Version

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