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Pigg phosphatidylinositol glycan anchor biosynthesis, class G [ Rattus norvegicus (Norway rat) ]

Gene ID: 100910143, updated on 13-Apr-2024

Summary

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Symbol
Piggprovided by RGD
Full Name
phosphatidylinositol glycan anchor biosynthesis, class Gprovided by RGD
Primary source
RGD:1560335
See related
Ensembl:ENSRNOG00000071170 AllianceGenome:RGD:1560335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560335
Summary
Predicted to enable CP2 mannose-ethanolamine phosphotransferase activity. Predicted to act upstream of or within GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human PIGG (phosphatidylinositol glycan anchor biosynthesis class G). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 108.5), Kidney (RPKM 105.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pigg in Genome Data Viewer
Location:
14p22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (1549891..1578174, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (1404911..1433199, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (1567713..1596004, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene transmembrane protein 271 Neighboring gene down-regulator of transcription 1 Neighboring gene coiled-coil domain containing 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol. Shishioh N, et al. J Biol Chem, 2005 Mar 11. PMID 15632136
  2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CP2 mannose-ethanolamine phosphotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GPI ethanolamine phosphate transferase 2
Names
GPI ethanolamine phosphate transferase 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427662.1 → NP_001414591.1  GPI ethanolamine phosphate transferase 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    M0R9J2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    1549891..1578174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250517.5 → XP_006250579.1  GPI ethanolamine phosphate transferase 2 isoform X4

    See identical proteins and their annotated locations for XP_006250579.1

    UniProtKB/TrEMBL
    A6KPG3
    Conserved Domains (2) summary
    COG1524
    Location:45 → 311
    Npp1; Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily [General function prediction only]
    cd16024
    Location:62 → 335
    GPI_EPT_2; GPI ethanolamine phosphate transferase 2; PIG-G

  2. XM_006250514.5 → XP_006250576.1  GPI ethanolamine phosphate transferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006250576.1

    UniProtKB/TrEMBL
    A6KPG3, M0RDM7
    Related
    ENSRNOP00000067732.3
    Conserved Domains (2) summary
    COG1524
    Location:45 → 311
    Npp1; Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily [General function prediction only]
    cd16024
    Location:62 → 335
    GPI_EPT_2; GPI ethanolamine phosphate transferase 2; PIG-G

  3. XM_006250515.5 → XP_006250577.1  GPI ethanolamine phosphate transferase 2 isoform X2

    See identical proteins and their annotated locations for XP_006250577.1

    UniProtKB/TrEMBL
    A6KPG3
    Conserved Domains (1) summary
    cd16024
    Location:1 → 265
    GPI_EPT_2; GPI ethanolamine phosphate transferase 2; PIG-G

  4. XM_039092608.2 → XP_038948536.1  GPI ethanolamine phosphate transferase 2 isoform X6

    Conserved Domains (1) summary
    cl23718
    Location:1 → 97
    ALP_like; alkaline phosphatases and sulfatases

  5. XM_063272800.1 → XP_063128870.1  GPI ethanolamine phosphate transferase 2 isoform X5

  6. XM_006250516.5 → XP_006250578.1  GPI ethanolamine phosphate transferase 2 isoform X3

    See identical proteins and their annotated locations for XP_006250578.1

    UniProtKB/TrEMBL
    A6KPG3
    Conserved Domains (1) summary
    cd16024
    Location:62 → 335
    GPI_EPT_2; GPI ethanolamine phosphate transferase 2; PIG-G

RNA

  1. XR_005493074.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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