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Med7 mediator complex subunit 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100911235, updated on 13-Apr-2024

Summary

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Official Symbol
Med7provided by RGD
Official Full Name
mediator complex subunit 7provided by RGD
Primary source
RGD:6494481
See related
Ensembl:ENSRNOG00000007053 AllianceGenome:RGD:6494481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Crsp9
Summary
Contributes to ubiquitin protein ligase activity. Involved in protein ubiquitination. Part of ubiquitin ligase complex. Orthologous to human MED7 (mediator complex subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 56.2), Testes (RPKM 50.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Med7 in Genome Data Viewer
Location:
10q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (31343613..31359192)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (30842330..30857873)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (31532190..31536405)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene IL2-inducible T-cell kinase Neighboring gene golgi associated RAB2 interactor family member 3 Neighboring gene histidine-rich glycoprotein-like Neighboring gene hepatitis A virus cellular receptor 2 Neighboring gene hepatitis A virus cellular receptor 1 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. Ryu S, et al. Nature, 1999 Feb 4. PMID 9989412
  2. Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Brower CS, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12149480, Free PMC Article
  3. The Mediator complex and transcription regulation. Poss ZC, et al. Crit Rev Biochem Mol Biol, 2013 Nov-Dec. PMID 24088064, Free PMC Article
  4. Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Malik S, et al. Mol Cell Biol, 2004 Sep. PMID 15340084, Free PMC Article
  5. Mediator and cohesin connect gene expression and chromatin architecture. Kagey MH, et al. Nature, 2010 Sep 23. PMID 20720539, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 7
Names
cofactor required for Sp1 transcriptional activation, subunit 9
mediator of RNA polymerase II transcription subunit 7-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286183.1 → NP_001273112.1  mediator of RNA polymerase II transcription subunit 7

    See identical proteins and their annotated locations for NP_001273112.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HDR5, D4A7V2
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    31343613..31359192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085002.2 → XP_038940930.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    UniProtKB/TrEMBL
    A6HDR5, D4A7V2
    Related
    ENSRNOP00000092450.1
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

  2. XM_063268249.1 → XP_063124319.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    UniProtKB/TrEMBL
    A6HDR5, D4A7V2

  3. XM_039085003.2 → XP_038940931.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    UniProtKB/TrEMBL
    A6HDR5, D4A7V2
    Related
    ENSRNOP00000079794.1
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

  4. XM_039085004.2 → XP_038940932.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    UniProtKB/TrEMBL
    A6HDR5, D4A7V2
    Related
    ENSRNOP00000097914.1
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

  5. XM_003750806.4 → XP_003750854.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    See identical proteins and their annotated locations for XP_003750854.1

    UniProtKB/TrEMBL
    A6HDR5, D4A7V2
    Related
    ENSRNOP00000081636.1
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

  6. XM_006246161.4 → XP_006246223.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    See identical proteins and their annotated locations for XP_006246223.1

    UniProtKB/TrEMBL
    A6HDR5, D4A7V2
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

  7. XM_063268247.1 → XP_063124317.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    UniProtKB/TrEMBL
    A6HDR5, D4A7V2

  8. XM_063268248.1 → XP_063124318.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    UniProtKB/TrEMBL
    A6HDR5, D4A7V2

  9. XM_039085006.2 → XP_038940934.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    UniProtKB/TrEMBL
    A6HDR5, D4A7V2
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

  10. XM_008767653.4 → XP_008765875.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    See identical proteins and their annotated locations for XP_008765875.1

    UniProtKB/TrEMBL
    A6HDR5, D4A7V2
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

  11. XM_006246158.5 → XP_006246220.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    See identical proteins and their annotated locations for XP_006246220.1

    UniProtKB/TrEMBL
    A6HDR5, D4A7V2
    Related
    ENSRNOP00000093726.1
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

  12. XM_003750804.4 → XP_003750852.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    See identical proteins and their annotated locations for XP_003750852.1

    UniProtKB/TrEMBL
    A6HDR5, D4A7V2
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

  13. XM_006246159.5 → XP_006246221.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    See identical proteins and their annotated locations for XP_006246221.1

    UniProtKB/TrEMBL
    A6HDR5, D4A7V2
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

  14. XM_039085007.2 → XP_038940935.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    UniProtKB/TrEMBL
    A6HDR5, D4A7V2
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

  15. XM_039085005.2 → XP_038940933.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    UniProtKB/TrEMBL
    A6HDR5, D4A7V2
    Related
    ENSRNOP00000086713.1
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein
Nucleotide Protein Strain
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