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Mars2 methionyl-tRNA synthetase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 100911305, updated on 8-Mar-2024

Summary

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Symbol
Mars2provided by RGD
Full Name
methionyl-tRNA synthetase 2, mitochondrialprovided by RGD
Primary source
RGD:1311527
See related
Ensembl:ENSRNOG00000065339 AllianceGenome:RGD:1311527
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311527
Summary
Predicted to enable methionine-tRNA ligase activity. Predicted to be involved in methionyl-tRNA aminoacylation. Predicted to be located in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 25 and spastic ataxia 3. Orthologous to human MARS2 (methionyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See Mars2 in Genome Data Viewer
Location:
9q31
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (64214935..64228408)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (56720408..56729991)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (61823441..61826357)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene glycine cleavage system H protein, mitochondrial pseudogene Neighboring gene MOB family member 4, phocein Neighboring gene raftlin family member 2 Neighboring gene boule homolog, RNA binding protein Neighboring gene uncharacterized LOC120094794 Neighboring gene uncharacterized LOC134480577 Neighboring gene phospholipase C-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the human mitochondrial methionyl-tRNA synthetase. Spencer AC, et al. Biochemistry, 2004 Aug 3. PMID 15274629
  2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables methionine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methionine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in methionyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methionyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
methionine--tRNA ligase, mitochondrial
Names
methionine--tRNA ligase, mitochondrial-like
methionine-tRNA synthetase 2 (mitochondrial)
methionyl-tRNA synthetase, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    64214935..64228408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084841.2 → XP_038940769.1  methionine--tRNA ligase, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl00015
    Location:37 → 301
    nt_trans; nucleotidyl transferase superfamily

  2. XM_039084842.2 → XP_038940770.1  methionine--tRNA ligase, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl00015
    Location:37 → 301
    nt_trans; nucleotidyl transferase superfamily

  3. XM_003750699.6 → XP_003750747.1  methionine--tRNA ligase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_003750747.1

    UniProtKB/TrEMBL
    A6IP18, D4A9V7
    Related
    ENSRNOP00000088692.1
    Conserved Domains (3) summary
    cd07957
    Location:388 → 532
    Anticodon_Ia_Met; Anticodon-binding domain of methionyl tRNA synthetases
    cd00814
    Location:37 → 379
    MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
    PRK11893
    Location:39 → 574
    PRK11893; methionyl-tRNA synthetase; Reviewed
Nucleotide Protein Strain
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