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Spred3 sprouty-related EVH1 domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 101809, updated on 30-Apr-2024

Summary

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Official Symbol
Spred3provided by MGI
Official Full Name
sprouty-related EVH1 domain containing 3provided by MGI
Primary source
MGI:MGI:2142186
See related
Ensembl:ENSMUSG00000037239 AllianceGenome:MGI:2142186
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spred-3; D130060H24Rik
Summary
Predicted to enable protein kinase binding activity. Involved in negative regulation of cell differentiation and negative regulation of signal transduction. Acts upstream of or within negative regulation of MAPK cascade. Located in plasma membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; extraembryonic component; and pancreas. Orthologous to human SPRED3 (sprouty related EVH1 domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 9.5), cortex adult (RPKM 5.5) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B1; 7 16.94 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28857208..28869286, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29157783..29170070, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ryanodine receptor 1, skeletal muscle Neighboring gene STARR-seq mESC enhancer starr_18458 Neighboring gene microRNA 1963 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29926525-29926755 Neighboring gene RAS guanyl releasing protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E9287 Neighboring gene family with sequence similarity 98, member C Neighboring gene STARR-positive B cell enhancer ABC_E8159 Neighboring gene STARR-positive B cell enhancer ABC_E1337 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 Neighboring gene gametogenetin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Negative regulation of TGFβ-induced lens epithelial to mesenchymal transition (EMT) by RTK antagonists. Zhao G, et al. Exp Eye Res, 2015 Mar. PMID 25576668
  2. Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred. Zhao G, et al. Exp Eye Res, 2018 May. PMID 29501879, Free PMC Article
  3. Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. Kato R, et al. Biochem Biophys Res Commun, 2003 Mar 21. PMID 12646235
  4. Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme. Sylvestersen KB, et al. Gene Expr Patterns, 2011 Jan-Feb. PMID 20934536
  5. Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia. Heng X, et al. Elife, 2017 May 10. PMID 28489004, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables stem cell factor receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of lens fiber cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sprouty-related, EVH1 domain-containing protein 3
Names
Sprouty-related EVH1 domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182927.3 → NP_891557.3  sprouty-related, EVH1 domain-containing protein 3

    See identical proteins and their annotated locations for NP_891557.3

    Status: VALIDATED

    Source sequence(s)
    BC062119, CF538218, EL606697
    Consensus CDS
    CCDS21065.1
    UniProtKB/Swiss-Prot
    Q6P6N5, Q7TNJ8
    UniProtKB/TrEMBL
    A0A0R4J0K0
    Related
    ENSMUSP00000046216.7, ENSMUST00000048923.7
    Conserved Domains (2) summary
    cd10574
    Location:2 → 105
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    pfam05210
    Location:294 → 391
    Sprouty; Sprouty protein (Spry)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28857208..28869286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030241962.2 → XP_030097822.1  sprouty-related, EVH1 domain-containing protein 3 isoform X1

    Conserved Domains (1) summary
    cd10574
    Location:93 → 198
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain

  2. XM_017321915.3 → XP_017177404.1  sprouty-related, EVH1 domain-containing protein 3 isoform X2

    Conserved Domains (1) summary
    cd10574
    Location:93 → 198
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P6N5.1 GenPept UniProtKB/Swiss-Prot:Q6P6N5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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