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Zfp174 zinc finger protein 174 [ Rattus norvegicus (Norway rat) ]

Gene ID: 102551846, updated on 13-Apr-2024

Summary

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Official Symbol
Zfp174provided by RGD
Official Full Name
zinc finger protein 174provided by RGD
Primary source
RGD:7498198
See related
Ensembl:ENSRNOG00000007655 AllianceGenome:RGD:7498198
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Znf174
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including actin cytoskeleton; cytosol; and nucleoplasm. Orthologous to human ZNF174 (zinc finger protein 174). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 23.4), Adrenal (RPKM 22.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp174 in Genome Data Viewer
Location:
10q12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (12169012..12182775, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (11666580..11676328, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (11928150..11935415, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene clusterin associated protein 1 Neighboring gene similar to human chromosome 16 open reading frame 90 Neighboring gene N(alpha)-acetyltransferase 60, NatF catalytic subunit Neighboring gene zinc finger protein 597 Neighboring gene olfactory receptor family 2 subfamily C member 1 Neighboring gene uncharacterized LOC134480755

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain. Ivanov D, et al. Mol Cell, 2005 Jan 7. PMID 15629724
  2. Isolation and characterization of a novel zinc-finger protein with transcription repressor activity. Williams AJ, et al. J Biol Chem, 1995 Sep 22. PMID 7673192
  3. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc finger protein 174

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001421389.1 → NP_001408318.1  zinc finger protein 174

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    D3ZNW1
    Related
    ENSRNOP00000010059.3, ENSRNOT00000010059.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    12169012..12182775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087055.2 → XP_038942983.1  zinc finger protein 174 isoform X2

    Conserved Domains (1) summary
    cl02605
    Location:42 → 152
    SCAN; SCAN oligomerization domain

  2. XM_039087054.2 → XP_038942982.1  zinc finger protein 174 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:213 → 268
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:189 → 209
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:187 → 209
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:230 → 254
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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