Slc6a20a solute carrier family 6 (neurotransmitter transporter), member 20A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc6a20aprovided by MGI
Official Full Name: solute carrier family 6 (neurotransmitter transporter), member 20Aprovided by MGI
Primary source: MGI:MGI:2143217
See related: Ensembl:ENSMUSG00000036814 AllianceGenome:MGI:2143217
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Xt3s1; Xtrp3s1; A730081N20Rik
Summary: Enables L-proline transmembrane transporter activity. Involved in proline import across plasma membrane. Acts upstream of or within amino-acid betaine transport and proline transmembrane transport. Located in apical plasma membrane. Is expressed in early conceptus; metanephros; and secondary oocyte. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to human SLC6A20 (solute carrier family 6 member 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 115.2), small intestine adult (RPKM 65.2) and 4 other tissues See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 9 F4; 9 74.26 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (123465972..123507897, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (123636907..123678832, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that a high-fat diet induces expression of two amino acid transporters (Slc6a20a, Slc36a1) in intestinal mucosa pointing to a specific and adaptive absorption of some amino acids in high-fat diet-induced obesity and glucose intolerance.
Title: Disturbed intestinal nitrogen homeostasis in a mouse model of high-fat diet-induced obesity and glucose intolerance.
We assessed two candidates for the betaine/proline transporter: SIT1 (IMINO; encoded by Slc6a20a) and PROT (Slc6a7). mRNA from both genes was present in eggs and 1-cell embryos.
Title: SIT1 is a betaine/proline transporter that is activated in mouse eggs after fertilization and functions until the 2-cell stage.
molecular cloning of two mouse homologues corresponding to the single human SLC6A20 gene: these have been named XT3 and XT3s1 [Xt3s1]
Title: Molecular cloning of the mouse IMINO system: an Na+- and Cl--dependent proline transporter.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

General gene information

Go to the top of the page Help

Markers

Slc6a20a (e-PCR), detects polymorphism
- UniSTS:525581

Slc6a20 (e-PCR), detects polymorphism
- UniSTS:498310

AU022428 (e-PCR)
- UniSTS:159939

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-proline transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-proline transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-proline transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino-acid betaine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neutral L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables proline:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables proline:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables proline:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables solute:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables solute:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within L-alpha-amino acid transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-proline import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-proline import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in L-proline import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amino-acid betaine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in amino-acid betaine transport	ISO Inferred from Sequence Orthology more info
involved_in glycine import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in glycine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in glycine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutral amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proline import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in proline import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proline transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proline transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: sodium- and chloride-dependent transporter XTRP3A

Names: IMINO-B; X transporter protein 3 similar 1; solute carrier family 6 member 20A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139142.2 → NP_631881.1 sodium- and chloride-dependent transporter XTRP3A

See identical proteins and their annotated locations for NP_631881.1

Status: PROVISIONAL

Source sequence(s)

BC118933

Consensus CDS

CCDS40817.1

UniProtKB/Swiss-Prot

Q3USE2, Q8VDB9

UniProtKB/TrEMBL

E9Q0H0

Related

ENSMUSP00000047690.7, ENSMUST00000040960.13

Conserved Domains (1) summary

cl00456
Location:2 → 577

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain