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TP53COR1 tumor protein p53 pathway corepressor 1 [ Homo sapiens (human) ]

Gene ID: 102800311, updated on 10-Mar-2024

Summary

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Official Symbol
TP53COR1provided by HGNC
Official Full Name
tumor protein p53 pathway corepressor 1provided by HGNC
Primary source
HGNC:HGNC:43652
See related
MIM:616343
Gene type
ncRNA
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
linc-p21; TRP53COR1; lincRNA-p21
Annotation information
not in current annotation release
Orthologs
mouse all
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Genomic context

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Location:
6p21.2

Bibliography

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Related articles in PubMed

  1. Reactive oxygen species-induced long intergenic noncoding RNA p21 accelerates abdominal aortic aneurysm formation by promoting secretary smooth muscle cell phenotypes. Wang S, et al. J Mol Cell Cardiol, 2023 Jan. PMID 36436251
  2. Biophysical characterisation of human LincRNA-p21 sense and antisense Alu inverted repeats. D'Souza MH, et al. Nucleic Acids Res, 2022 Jun 10. PMID 35639511, Free PMC Article
  3. Long intergenic non-coding RNA-p21 is associated with poor prognosis in chronic lymphocytic leukemia. Abo Elwafa R, et al. Clin Transl Oncol, 2021 Jan. PMID 32468342
  4. LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling. Luo J, et al. Nat Commun, 2019 Jun 12. PMID 31189930, Free PMC Article
  5. LincRNA-p21 enhances the sensitivity of radiotherapy for gastric cancer by targeting the β-catenin signaling pathway. Chen L, et al. J Cell Biochem, 2019 Apr. PMID 30484893

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reactive oxygen species-induced long intergenic noncoding RNA p21 accelerates abdominal aortic aneurysm formation by promoting secretary smooth muscle cell phenotypes.
    Title: Reactive oxygen species-induced long intergenic noncoding RNA p21 accelerates abdominal aortic aneurysm formation by promoting secretary smooth muscle cell phenotypes.
  2. Biophysical characterisation of human LincRNA-p21 sense and antisense Alu inverted repeats.
    Title: Biophysical characterisation of human LincRNA-p21 sense and antisense Alu inverted repeats.
  3. Downregulation of long non-coding RNAs in patients with bipolar disorder.
    Title: Downregulation of long non-coding RNAs in patients with bipolar disorder.
  4. p53-Dependent LincRNA-p21 Protects Against Proliferation and Anti-apoptosis of Vascular Smooth Muscle Cells in Atherosclerosis by Upregulating SIRT7 via MicroRNA-17-5p.
    Title: p53-Dependent LincRNA-p21 Protects Against Proliferation and Anti-apoptosis of Vascular Smooth Muscle Cells in Atherosclerosis by Upregulating SIRT7 via MicroRNA-17-5p.
  5. Long intergenic non-coding RNA-p21 is associated with poor prognosis in chronic lymphocytic leukemia.
    Title: Long intergenic non-coding RNA-p21 is associated with poor prognosis in chronic lymphocytic leukemia.
  6. Exosomal lncRNA-p21 derived from mesenchymal stem cells protects epithelial cells during LPS-induced acute lung injury by sponging miR-181.
    Title: Exosomal lncRNA-p21 derived from mesenchymal stem cells protects epithelial cells during LPS-induced acute lung injury by sponging miR-181.
  7. LincRNA-p21 participates in thoracic aortic aneurysms (TAA) by regulating the proliferation and apoptosis of vascular smooth muscle cells through the activation of TGF-b1 signaling pathway.
    Title: Upregulation of lincRNA-p21 in thoracic aortic aneurysms is involved in the regulation of proliferation and apoptosis of vascular smooth muscle cells by activating TGF-β1 signaling pathway.
  8. Results demonstrated that linc-p21 expression level was downregulated in gastric cancer (GC) cells and tissues and its overexpression suppressed the GC cell growth, cell cycle, and migration as well as the radiosensitivity by regulating the beta-catenin signaling pathway. These data suggested that lincRNA-p21 acted as a tumor suppressor gene in the development of GC.
    Title: LincRNA-p21 enhances the sensitivity of radiotherapy for gastric cancer by targeting the β-catenin signaling pathway.
  9. lincRNA-p21 suppresses the bladder cancer cell growth through inhibiting glutaminase and glutamine catabolism.
    Title: LincRNA-p21 suppresses glutamine catabolism and bladder cancer cell growth through inhibiting glutaminase expression.
  10. Study found that lncRNA-p21 is highly expressed in the neuroendocrine prostate cancer (NEPC) patients derived xenograft tissues. Results from cell lines and human clinical sample surveys also revealed that lncRNA-p21 expression is up-regulated in NEPC and antiandrogen enzalutamide treatment could increase the lncRNA-p21 to induce the neuroendocrine differentiation.
    Title: LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling.
Submit: New GeneRIF Correction See all GeneRIFs (21)

General gene information

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Homology

Other Names

  • tumor protein p53 pathway corepressor 1 (non-protein coding)
Nucleotide Protein
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