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Zc3h10 zinc finger CCCH type containing 10 [ Mus musculus (house mouse) ]

Gene ID: 103284, updated on 11-Apr-2024

Summary

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Official Symbol
Zc3h10provided by MGI
Official Full Name
zinc finger CCCH type containing 10provided by MGI
Primary source
MGI:MGI:2143670
See related
Ensembl:ENSMUSG00000039810 AllianceGenome:MGI:2143670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable miRNA binding activity. Predicted to be involved in negative regulation of production of miRNAs involved in gene silencing by miRNA; posttranscriptional regulation of gene expression; and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human ZC3H10 (zinc finger CCCH-type containing 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 16.0), ovary adult (RPKM 11.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zc3h10 in Genome Data Viewer
Location:
10 D3; 10 77.01 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128379429..128383877, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128543560..128548008, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene Riken cDNA A430046D13 gene Neighboring gene extended synaptotagmin-like protein 1 Neighboring gene microRNA 6916 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127962008-127962317 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127962362-127962471 Neighboring gene STARR-positive B cell enhancer ABC_E90 Neighboring gene STARR-positive B cell enhancer ABC_E3927 Neighboring gene STARR-positive B cell enhancer ABC_E8870 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127984844-127985032 Neighboring gene STARR-positive B cell enhancer ABC_E2973 Neighboring gene ribosomal protein L41 Neighboring gene predicted gene 9176

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zc3h10 regulates adipogenesis by controlling translation and F-actin/mitochondria interaction. Audano M, et al. J Cell Biol, 2021 Mar 1. PMID 33566069, Free PMC Article
  2. Zc3h10 is a novel mitochondrial regulator. Audano M, et al. EMBO Rep, 2018 Apr. PMID 29507079, Free PMC Article
  3. Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes. Yi D, et al. Elife, 2020 Oct 27. PMID 33107819, Free PMC Article
  4. Zc3h10 Acts as a Transcription Factor and Is Phosphorylated to Activate the Thermogenic Program. Yi D, et al. Cell Rep, 2019 Nov 26. PMID 31775033, Free PMC Article
  5. Gene trapping identifies a putative tumor suppressor and a new inducer of cell migration. Guardiola-Serrano F, et al. Biochem Biophys Res Commun, 2008 Nov 28. PMID 18814840

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zc3h10 regulates adipogenesis by controlling translation and F-actin/mitochondria interaction.
    Title: Zc3h10 regulates adipogenesis by controlling translation and F-actin/mitochondria interaction.
  2. Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes.
    Title: Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes.
  3. our study identifies Zc3h10 as a novel mitochondrial regulator.
    Title: Zc3h10 is a novel mitochondrial regulator.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of miRNA processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger CCCH domain-containing protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134003.2 → NP_598764.1  zinc finger CCCH domain-containing protein 10

    See identical proteins and their annotated locations for NP_598764.1

    Status: VALIDATED

    Source sequence(s)
    AC117232, AK050662, BB842371, BY441443
    Consensus CDS
    CCDS24281.1
    UniProtKB/Swiss-Prot
    Q8R205
    Related
    ENSMUSP00000042727.4, ENSMUST00000040572.10
    Conserved Domains (2) summary
    smart00356
    Location:134 → 158
    ZnF_C3H1; zinc finger
    pfam06005
    Location:243 → 279
    ZapB; Cell division protein ZapB

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128379429..128383877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513013.3 → XP_006513076.1  zinc finger CCCH domain-containing protein 10 isoform X1

    See identical proteins and their annotated locations for XP_006513076.1

    UniProtKB/Swiss-Prot
    Q8R205
    Conserved Domains (2) summary
    smart00356
    Location:134 → 158
    ZnF_C3H1; zinc finger
    pfam06005
    Location:243 → 279
    ZapB; Cell division protein ZapB
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R205.1 GenPept UniProtKB/Swiss-Prot:Q8R205

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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