Npffr2 neuropeptide FF receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npffr2provided by MGI
Official Full Name: neuropeptide FF receptor 2provided by MGI
Primary source: MGI:MGI:1860130
See related: Ensembl:ENSMUSG00000035528 AllianceGenome:MGI:1860130
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HG31; Gpr74; NPFF2
Summary: Predicted to enable G protein-coupled receptor activity and peptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in actin cytoskeleton and plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in brain; dorsal root ganglion; and trigeminal ganglion. Orthologous to human NPFFR2 (neuropeptide FF receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 5 E1; 5 44.32 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (89674805..89731473)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (89526840..89583914)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypothalamic NPFFR2 attenuates central insulin signaling and its knockout diminishes metabolic dysfunction in mouse models of diabetes mellitus.
Title: Hypothalamic NPFFR2 attenuates central insulin signaling and its knockout diminishes metabolic dysfunction in mouse models of diabetes mellitus.
NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose.
Title: NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose.
Knockout of NPFFR2 Prevents LPS-Induced Depressive-Like Responses in Mice.
Title: Knockout of NPFFR2 Prevents LPS-Induced Depressive-Like Responses in Mice.
Ablation of NPFFR2 in Mice Reduces Response to Single Prolonged Stress Model.
Title: Ablation of NPFFR2 in Mice Reduces Response to Single Prolonged Stress Model.
NPFFR2 signalling promotes diet-induced thermogenesis.
Title: Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling.
These data underlie kisspeptin's hyperalgesic action and argues for the role of kisspeptin receptor 1 in the mediation of its action. Furthermore, our results suggest that central KP-13 administration can modify the acute effects of morphine.
Title: Kisspeptin modulates pain sensitivity of CFLP mice.
we demonstrate, for the first time, that NPFFR2 positively modulates the HPA axis via hypothalamic corticotropin-releasing factor (CRF). Our finding that NPFFR2 regulates stress-dependent neural pathways advances our understanding of neuroendocrine regulation and opens new avenues for probing the functions of NPFF.
Title: NPFFR2 Activates the HPA Axis and Induces Anxiogenic Effects in Rodents.
Neuro 2A cells endogenously expressed NPFF2 receptor, and the NPFF2 receptor agonist dNPA inhibited cyclic adenosine monophosphate (cAMP) production stimulated by forskolin in Neuro 2A cells.
Title: Activation of NPFF(2) receptor stimulates neurite outgrowth in Neuro 2A cells through activation of ERK signaling pathway.
The results of this study demonstrated that NPFFR2 activation modulates pain transmission by up-regulating the pain mediator CGRP, leading to hyperalgesia.
Title: Activation of NPFFR2 leads to hyperalgesia through the spinal inflammatory mediator CGRP in mice.
Results indicate that NPFF signaling through NPFFR2 contributes to diabetic corneal nerve injury recovery and epithelial wound healing. Neuropeptide FF is a potential neuroregenerative factor for diabetic sensory nerve injury.
Title: Neuropeptide FF Promotes Recovery of Corneal Nerve Injury Associated With Hyperglycemia.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IEA Inferred from Electronic Annotation more info
enables opioid receptor binding	IEA Inferred from Electronic Annotation more info
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of adenylate cyclase activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of cAMP-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: neuropeptide FF receptor 2

Names: G-protein coupled receptor 74; neuropeptide NPFF receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412387.1 → NP_001399316.1 neuropeptide FF receptor 2

Status: VALIDATED

Source sequence(s)

AC134840

UniProtKB/Swiss-Prot

Q8BKR6, Q924H0
NM_133192.4 → NP_573455.2 neuropeptide FF receptor 2

See identical proteins and their annotated locations for NP_573455.2

Status: VALIDATED

Source sequence(s)

AC134840

Consensus CDS

CCDS19408.1

UniProtKB/Swiss-Prot

Q8BKR6, Q924H0

UniProtKB/TrEMBL

Q924N0

Related

ENSMUSP00000040033.3, ENSMUST00000048557.3

Conserved Domains (2) summary

cd14964
Location:48 → 72

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:46 → 343

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily