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CENPF centromere protein F [ Homo sapiens (human) ]

Gene ID: 1063, updated on 5-Jan-2025

Summary

Official Symbol
CENPFprovided by HGNC
Official Full Name
centromere protein Fprovided by HGNC
Primary source
HGNC:HGNC:1857
See related
Ensembl:ENSG00000117724 MIM:600236; AllianceGenome:HGNC:1857
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CENF; hcp-1; CILD31; STROMS; PRO1779
Summary
This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 9.7), testis (RPKM 6.0) and 15 other tissues See more
Orthologs
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Genomic context

See CENPF in Genome Data Viewer
Location:
1q41
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (214603195..214664571)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (213842449..213903796)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (214776538..214837914)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase non-receptor type 14 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:214656924-214657632 Neighboring gene adaptor related protein complex 3 subunit sigma 1 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:214678347-214679324 Neighboring gene Sharpr-MPRA regulatory region 6950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:214698971-214699854 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:214723608-214724429 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:214724430-214725250 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:214725251-214726071 Neighboring gene keratin 18 pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1815 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:214788162-214789361 Neighboring gene ABHD17A pseudogene 3 Neighboring gene UBE2V1 pseudogene 13 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:214856916-214857577 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:214900550-214901086 Neighboring gene uncharacterized LOC105372916 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:214996426-214997625 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 24

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Stromme syndrome
MedGen: C1855705 OMIM: 243605 GeneReviews: Stromme Syndrome
Compare labs

EBI GWAS Catalog

Description
Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates CENPF in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding PubMed 
enables chromatin binding PubMed 
enables dynein complex binding  
enables dynein complex binding PubMed 
enables microtubule binding  
enables protein binding PubMed 
enables protein homodimerization activity PubMed 
Process Evidence Code Pubs
involved_in DNA biosynthetic process  
involved_in cell differentiation  
involved_in cell division  
involved_in chromosome segregation PubMed 
involved_in chromosome segregation PubMed 
involved_in kidney development PubMed 
involved_in kinetochore assembly PubMed 
involved_in metaphase chromosome alignment  
involved_in metaphase chromosome alignment PubMed 
involved_in mitotic cell cycle  
involved_in mitotic cell cycle PubMed 
involved_in mitotic spindle assembly checkpoint signaling PubMed 
involved_in muscle organ development  
involved_in negative regulation of DNA-templated transcription PubMed 
involved_in protein transport PubMed 
involved_in protein transport PubMed 
involved_in regulation of G2/M transition of mitotic cell cycle  
involved_in regulation of G2/M transition of mitotic cell cycle PubMed 
involved_in regulation of striated muscle tissue development PubMed 
involved_in response to xenobiotic stimulus PubMed 
involved_in ventricular system development PubMed 
Items 1 - 20 of 25
Component Evidence Code Pubs
located_in axoneme  
located_in centrosome  
located_in chromatin PubMed 
is_active_in chromosome, centromeric region  
located_in chromosome, centromeric region PubMed 
located_in ciliary basal body  
part_of ciliary transition fiber PubMed 
located_in cytoplasm PubMed 
located_in cytosol  
located_in cytosol  
located_in kinetochore PubMed 
located_in midbody PubMed 
located_in nuclear envelope PubMed 
located_in nuclear matrix PubMed 
located_in nuclear membrane  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus PubMed 
part_of outer kinetochore PubMed 
part_of outer kinetochore PubMed 
located_in perinuclear region of cytoplasm  
located_in pronucleus  
located_in spindle PubMed 
is_active_in spindle pole  
located_in spindle pole PubMed 
Items 1 - 20 of 25

General protein information

Preferred Names
centromere protein F
Names
AH antigen
CENP-F kinetochore protein
cell-cycle-dependent 350K nuclear protein
centromere protein F, 350/400kDa
kinetochore protein CENPF
mitosin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046787.1 RefSeqGene

    Range
    5017..66393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016343.4NP_057427.3  centromere protein F

    See identical proteins and their annotated locations for NP_057427.3

    Status: REVIEWED

    Source sequence(s)
    BG680819, BQ774943, BU155312, BU662228, CD654009, U30872
    Consensus CDS
    CCDS31023.1
    UniProtKB/Swiss-Prot
    P49454, Q13171, Q13246, Q5VVM7
    Related
    ENSP00000355922.3, ENST00000366955.8
    Conserved Domains (6) summary
    COG1196
    Location:9011654
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:2831160
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR04523
    Location:23922887
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam10473
    Location:21312270
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam10481
    Location:1307
    CENP-F_N; Cenp-F N-terminal domain
    pfam10490
    Location:29673013
    CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    214603195..214664571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509082.4XP_011507384.1  centromere protein F isoform X2

    UniProtKB/TrEMBL
    A0A9L9PXU7
    Related
    ENSP00000516538.1, ENST00000706765.1
    Conserved Domains (5) summary
    COG1196
    Location:9011654
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:2831160
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10473
    Location:21312270
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam10481
    Location:1307
    CENP-F_N; Cenp-F N-terminal domain
    pfam10490
    Location:29082954
    CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1
  2. XM_017000086.3XP_016855575.1  centromere protein F isoform X1

    UniProtKB/Swiss-Prot
    P49454, Q13171, Q13246, Q5VVM7
    Conserved Domains (6) summary
    COG1196
    Location:9011654
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:2831160
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR04523
    Location:23922887
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam10473
    Location:21312270
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam10481
    Location:1307
    CENP-F_N; Cenp-F N-terminal domain
    pfam10490
    Location:29673013
    CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    213842449..213903796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333892.1XP_054189867.1  centromere protein F isoform X2

  2. XM_054333891.1XP_054189866.1  centromere protein F isoform X1

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