U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mpig6b megakaryocyte and platelet inhibitory receptor G6b [ Mus musculus (house mouse) ]

Gene ID: 106722, updated on 14-May-2024

Summary

Go to the top of the page Help
Official Symbol
Mpig6bprovided by MGI
Official Full Name
megakaryocyte and platelet inhibitory receptor G6bprovided by MGI
Primary source
MGI:MGI:2146995
See related
Ensembl:ENSMUSG00000073414 AllianceGenome:MGI:2146995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G6b; Ng31; C6orf25
Summary
Acts upstream of or within blood coagulation; integrin-mediated signaling pathway; and myeloid cell differentiation. Predicted to be located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human MPIG6B (megakaryocyte and platelet inhibitory receptor G6b). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 1.4), testis adult (RPKM 1.3) and 19 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Mpig6b in Genome Data Viewer
Location:
17 B1; 17 18.59 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35281669..35285761, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35062693..35066848, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42445 Neighboring gene chloride intracellular channel 1 Neighboring gene STARR-positive B cell enhancer ABC_E11641 Neighboring gene DDAH family member 2, ADMA independent Neighboring gene G6b opposite strand Neighboring gene lymphocyte antigen 6 family member G6C Neighboring gene lymphocyte antigen 6 family member G6D Neighboring gene STARR-seq mESC enhancer starr_42446 Neighboring gene lymphocyte antigen 6 family member G6E

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B. Vögtle T, et al. Elife, 2019 Aug 22. PMID 31436532, Free PMC Article
  2. Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis. Geer MJ, et al. Blood, 2018 Sep 27. PMID 29891536, Free PMC Article
  3. Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function. Mazharian A, et al. Blood, 2013 May 16. PMID 23509158, Free PMC Article
  4. Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function. Mazharian A, et al. Sci Signal, 2012 Oct 30. PMID 23112346, Free PMC Article
  5. Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. West DB, et al. PLoS Genet, 2016 Feb. PMID 26839965, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Uncoupling of G6b-B from Shp1 and Shp2 results in severe macrothrombocytopenia and aberrant platelet function.
    Title: Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis.
  2. these findings establish G6b-B as a major inhibitory receptor regulating megakaryocyte activation, function, and platelet production.
    Title: Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within blood coagulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in megakaryocyte development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within megakaryocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in platelet formation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within platelet formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within platelet formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
megakaryocyte and platelet inhibitory receptor G6b
Names
ITIM-receptor G6b-B
immunoreceptor tyrosine-based inhibitory motif (ITIM) containing platelet receptor
protein G6b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033221.3 → NP_001028393.1  megakaryocyte and platelet inhibitory receptor G6b isoform 2 precursor

    See identical proteins and their annotated locations for NP_001028393.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AK137516
    Consensus CDS
    CCDS28676.1
    UniProtKB/TrEMBL
    D3YVS6
    Related
    ENSMUSP00000094950.2, ENSMUST00000097337.8
    Conserved Domains (1) summary
    pfam15096
    Location:20 → 165
    G6B; G6B family

  2. NM_001191012.1 → NP_001177941.1  megakaryocyte and platelet inhibitory receptor G6b isoform 1 precursor

    See identical proteins and their annotated locations for NP_001177941.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK137516, GU269270
    Consensus CDS
    CCDS57071.1
    UniProtKB/Swiss-Prot
    D7PDD4
    Related
    ENSMUSP00000133377.2, ENSMUST00000174190.2
    Conserved Domains (1) summary
    pfam15096
    Location:20 → 242
    G6B; G6B family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35281669..35285761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523419.5 → XP_006523482.1  megakaryocyte and platelet inhibitory receptor G6b isoform X1

    See identical proteins and their annotated locations for XP_006523482.1

    Conserved Domains (1) summary
    pfam15096
    Location:20 → 289
    G6B; G6B family

  2. XM_011246241.4 → XP_011244543.1  megakaryocyte and platelet inhibitory receptor G6b isoform X2

    See identical proteins and their annotated locations for XP_011244543.1

    Conserved Domains (1) summary
    pfam15096
    Location:20 → 167
    G6B; G6B family

  3. XM_006523420.5 → XP_006523483.1  megakaryocyte and platelet inhibitory receptor G6b isoform X3

    See identical proteins and their annotated locations for XP_006523483.1

    Conserved Domains (1) summary
    pfam15096
    Location:20 → 185
    G6B; G6B family

RNA

  1. XR_876452.4 RNA Sequence

  2. XR_876451.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D7PDD4.1 GenPept UniProtKB/Swiss-Prot:D7PDD4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous