Uqcc3 ubiquinol-cytochrome c reductase complex assembly factor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uqcc3provided by MGI
Official Full Name: ubiquinol-cytochrome c reductase complex assembly factor 3provided by MGI
Primary source: MGI:MGI:2147553
See related: Ensembl:ENSMUSG00000071654 AllianceGenome:MGI:2147553
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cbp4
Summary: Predicted to enable cardiolipin binding activity and phosphatidic acid binding activity. Predicted to be involved in cristae formation; mitochondrial electron transport, ubiquinol to cytochrome c; and mitochondrial respiratory chain complex III assembly. Predicted to act upstream of or within ATP biosynthetic process. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be part of mitochondrial respiratory chain complex III. Predicted to be integral component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 9. Orthologous to human UQCC3 (ubiquinol-cytochrome c reductase complex assembly factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 22.9), kidney adult (RPKM 19.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.9 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (8857378..8858297, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (8880014..8880933, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The eIF2 kinase pathway induces both pro-survival and pro-apoptotic pathways.
Title: The eukaryotic initiation factor-2 kinase pathway facilitates differential GADD45a expression in response to environmental stress.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237886

AI462493 (e-PCR)
- UniSTS:181194

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cardiolipin binding	ISO Inferred from Sequence Orthology more info
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ATP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cristae formation	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex III assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respiratory chain complex III assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial respiratory chain complex III	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquinol-cytochrome-c reductase complex assembly factor 3

Names: UPF0723 protein C11orf83 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.