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Coro2a coronin, actin binding protein 2A [ Mus musculus (house mouse) ]

Gene ID: 107684, updated on 5-Mar-2024

Summary

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Official Symbol
Coro2aprovided by MGI
Official Full Name
coronin, actin binding protein 2Aprovided by MGI
Primary source
MGI:MGI:1345966
See related
Ensembl:ENSMUSG00000028337 AllianceGenome:MGI:1345966
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IR10; 9030208C03Rik
Summary
Predicted to enable actin filament binding activity. Located in brush border. Is expressed in several structures, including alimentary system; nervous system; nose; spleen; and testis. Orthologous to human CORO2A (coronin 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 92.0), colon adult (RPKM 68.6) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 B1; 4 24.87 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (46536937..46601929, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (46536937..46601929, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3487 Neighboring gene predicted gene, 22247 Neighboring gene N-acetylneuraminic acid synthase (sialic acid synthase) Neighboring gene tripartite motif-containing 14 Neighboring gene STARR-positive B cell enhancer ABC_E3488 Neighboring gene predicted gene, 54223 Neighboring gene predicted gene, 16731 Neighboring gene STARR-positive B cell enhancer ABC_E4623 Neighboring gene STARR-positive B cell enhancer ABC_E3489 Neighboring gene STARR-positive B cell enhancer ABC_E3490 Neighboring gene predicted gene, 54221 Neighboring gene STARR-positive B cell enhancer ABC_E6173 Neighboring gene predicted gene, 54222 Neighboring gene STARR-positive B cell enhancer ABC_E2111 Neighboring gene TBC1 domain family, member 2 Neighboring gene predicted gene, 31850 Neighboring gene predicted gene, 42281

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Huang W, et al. Nature, 2011 Feb 17. PMID 21331046, Free PMC Article
  2. The coronin family of actin-associated proteins. de Hostos EL. Trends Cell Biol, 1999 Sep. PMID 10461187
  3. Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein. Okumura M, et al. DNA Cell Biol, 1998 Sep. PMID 9778037
  4. Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival. Suo D, et al. Nat Neurosci, 2014 Jan. PMID 24270184, Free PMC Article
  5. A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Revenu C, et al. Mol Biol Cell, 2012 Jan. PMID 22114352, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in brush border IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
coronin-2A
Names
coronin 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164804.1 → NP_001158276.1  coronin-2A isoform 2

    See identical proteins and their annotated locations for NP_001158276.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK030971, AK054394, AL683884, AW912496
    Consensus CDS
    CCDS18154.1
    UniProtKB/Swiss-Prot
    Q3U6H8, Q8BW42, Q8C0P5
    UniProtKB/TrEMBL
    B1AVH4, Q3U4G8
    Related
    ENSMUSP00000103385.3, ENSMUST00000107756.4
    Conserved Domains (2) summary
    sd00039
    Location:40 → 80
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10 → 517
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_178893.4 → NP_849224.2  coronin-2A isoform 1

    See identical proteins and their annotated locations for NP_849224.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK030097, AK030971, AL683884
    Consensus CDS
    CCDS71383.1
    UniProtKB/TrEMBL
    B1AVH5, Q3U4G8
    Related
    ENSMUSP00000103386.2, ENSMUST00000107757.8
    Conserved Domains (2) summary
    sd00039
    Location:59 → 99
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:29 → 536
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    46536937..46601929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163567.1 → XP_036019460.1  coronin-2A isoform X2

    UniProtKB/Swiss-Prot
    Q3U6H8, Q8BW42, Q8C0P5
    UniProtKB/TrEMBL
    B1AVH4, Q3U4G8
    Conserved Domains (2) summary
    sd00039
    Location:40 → 80
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10 → 517
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_011249899.4 → XP_011248201.1  coronin-2A isoform X1

    See identical proteins and their annotated locations for XP_011248201.1

    UniProtKB/TrEMBL
    B1AVH5, Q3U4G8
    Conserved Domains (2) summary
    sd00039
    Location:59 → 99
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:29 → 536
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0P5.1 GenPept UniProtKB/Swiss-Prot:Q8C0P5

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