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Grm3 glutamate receptor, metabotropic 3 [ Mus musculus (house mouse) ]

Gene ID: 108069, updated on 21-Apr-2024

Summary

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Official Symbol
Grm3provided by MGI
Official Full Name
glutamate receptor, metabotropic 3provided by MGI
Primary source
MGI:MGI:1351340
See related
Ensembl:ENSMUSG00000003974 AllianceGenome:MGI:1351340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mGlu3; Gprc1c; mGluR3; 0710001G23Rik
Summary
Enables calcium channel regulator activity and group II metabotropic glutamate receptor activity. Acts upstream of or within gene expression. Located in several cellular components, including glutamatergic synapse; postsynaptic density; and synaptic membrane. Is integral component of postsynaptic membrane. Is integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and visual system. Orthologous to human GRM3 (glutamate metabotropic receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 11.5), frontal lobe adult (RPKM 9.3) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 A1; 5 3.69 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (9535235..9776087, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (9485236..9725352, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene endosome-lysosome associated apoptosis and autophagy regulator family member 2 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene Neighboring gene STARR-seq mESC enhancer starr_12413 Neighboring gene STARR-seq mESC enhancer starr_12414 Neighboring gene microRNA 879 Neighboring gene STARR-seq mESC enhancer starr_12415 Neighboring gene STARR-seq mESC enhancer starr_12416 Neighboring gene STARR-seq mESC enhancer starr_12417 Neighboring gene predicted gene, 23312 Neighboring gene predicted gene, 35139

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A metabotropic glutamate receptor 3 (mGlu3R) isoform playing neurodegenerative roles in astrocytes is prematurely up-regulated in an Alzheimer's model. Turati J, et al. J Neurochem, 2022 May. PMID 35411603
  2. Group II metabotropic glutamate receptor (mGlu(2) and mGlu(3) ) roles in thalamic processing. Copeland CS, et al. Br J Pharmacol, 2022 Apr. PMID 34355803
  3. Frontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mGlu(3)) impairs postsynaptic plasticity and modulates affective behaviors. Joffe ME, et al. Neuropsychopharmacology, 2021 Nov. PMID 34035469, Free PMC Article
  4. mGlu3 receptor regulates microglial cell reactivity in neonatal rats. Zinni M, et al. J Neuroinflammation, 2021 Jan 6. PMID 33407565, Free PMC Article
  5. Metabotropic glutamate receptor 3 is downregulated and its expression is shifted from neurons to astrocytes in the mouse lateral septum during the postpartum period. Zhao C, et al. J Histochem Cytochem, 2015 Jun. PMID 25739438, Free PMC Article

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A metabotropic glutamate receptor 3 (mGlu3R) isoform playing neurodegenerative roles in astrocytes is prematurely up-regulated in an Alzheimer's model.
    Title: A metabotropic glutamate receptor 3 (mGlu3R) isoform playing neurodegenerative roles in astrocytes is prematurely up-regulated in an Alzheimer's model.
  2. Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice.
    Title: Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice.
  3. Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice.
    Title: Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice.
  4. mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice.
    Title: mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice.
  5. Frontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mGlu3) impairs postsynaptic plasticity and modulates affective behaviors.
    Title: Frontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mGlu(3)) impairs postsynaptic plasticity and modulates affective behaviors.
  6. Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.
    Title: Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.
  7. mGlu3 receptor regulates microglial cell reactivity in neonatal rats.
    Title: mGlu3 receptor regulates microglial cell reactivity in neonatal rats.
  8. Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus.
    Title: Activating mGlu(3) Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus.
  9. The effect of mGlu2/3 receptors on synaptic activities to different types of GABAergic interneurons in the anterior cingulate cortex.
    Title: The effect of mGlu2/3 receptors on synaptic activities to different types of GABAergic interneurons in the anterior cingulate cortex.
  10. hese findings suggest that mGlu3 receptors have a strong impact on the development of cortical GABAergic transmission and cortical neural synchronization mechanisms corroborating the concept that genetic variants of mGlu3 receptors may predispose to psychiatric disorders.
    Title: Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables group II metabotropic glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables group II metabotropic glutamate receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables group II metabotropic glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to stress IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic modulation of chemical synaptic transmission EXP
Inferred from Experiment
more info
 PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of sensory perception of pain NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of pain TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic transmission, glutamatergic TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in astrocyte projection ISO
Inferred from Sequence Orthology
more info
  
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynaptic active zone NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
metabotropic glutamate receptor 3
Names
G protein-coupled receptor, family C, group 1, member C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417964.1 → NP_001404893.1  metabotropic glutamate receptor 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC157555, AC162520
    UniProtKB/Swiss-Prot
    Q14DJ9, Q9QYS2

  2. NM_181850.3 → NP_862898.1  metabotropic glutamate receptor 3 precursor

    See identical proteins and their annotated locations for NP_862898.1

    Status: VALIDATED

    Source sequence(s)
    AC157555, AC162520
    Consensus CDS
    CCDS19090.1
    UniProtKB/Swiss-Prot
    Q14DJ9, Q9QYS2
    Related
    ENSMUSP00000004076.4, ENSMUST00000004076.5
    Conserved Domains (3) summary
    cd15448
    Location:575 → 828
    7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06375
    Location:33 → 494
    PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor
    pfam07562
    Location:505 → 555
    NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    9535235..9776087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164718.1 → XP_036020611.1  metabotropic glutamate receptor 3 isoform X1

    UniProtKB/Swiss-Prot
    Q14DJ9, Q9QYS2
    Conserved Domains (3) summary
    cd15448
    Location:575 → 828
    7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06375
    Location:33 → 494
    PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor
    pfam07562
    Location:505 → 555
    NCD3G; Nine Cysteines Domain of family 3 GPCR

  2. XM_036164719.1 → XP_036020612.1  metabotropic glutamate receptor 3 isoform X1

    UniProtKB/Swiss-Prot
    Q14DJ9, Q9QYS2
    Conserved Domains (3) summary
    cd15448
    Location:575 → 828
    7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06375
    Location:33 → 494
    PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor
    pfam07562
    Location:505 → 555
    NCD3G; Nine Cysteines Domain of family 3 GPCR

  3. XM_036164720.1 → XP_036020613.1  metabotropic glutamate receptor 3 isoform X1

    UniProtKB/Swiss-Prot
    Q14DJ9, Q9QYS2
    Conserved Domains (3) summary
    cd15448
    Location:575 → 828
    7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06375
    Location:33 → 494
    PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor
    pfam07562
    Location:505 → 555
    NCD3G; Nine Cysteines Domain of family 3 GPCR
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYS2.1 GenPept UniProtKB/Swiss-Prot:Q9QYS2

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