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Napg N-ethylmaleimide sensitive fusion protein attachment protein gamma [ Mus musculus (house mouse) ]

Gene ID: 108123, updated on 11-Apr-2024

Summary

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Official Symbol
Napgprovided by MGI
Official Full Name
N-ethylmaleimide sensitive fusion protein attachment protein gammaprovided by MGI
Primary source
MGI:MGI:104561
See related
Ensembl:ENSMUSG00000024581 AllianceGenome:MGI:104561
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SNARE; 2400003O04Rik
Summary
Predicted to enable soluble NSF attachment protein activity and syntaxin binding activity. Predicted to be involved in intracellular protein transport. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Located in myelin sheath. Orthologous to human NAPG (NSF attachment protein gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 25.8), frontal lobe adult (RPKM 24.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Napg in Genome Data Viewer
Location:
18 E1; 18 35.95 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (63110910..63132521)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (62977836..62999450)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41752 Neighboring gene adenomatosis polyposis coli down-regulated 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:63137389-63137586 Neighboring gene STARR-seq mESC enhancer starr_44784 Neighboring gene piezo-type mechanosensitive ion channel component 2 Neighboring gene predicted gene, 36651 Neighboring gene STARR-seq mESC enhancer starr_44785 Neighboring gene STARR-seq mESC enhancer starr_44786 Neighboring gene STARR-seq mESC enhancer starr_44787 Neighboring gene STARR-seq mESC enhancer starr_44788 Neighboring gene predicted gene, 26972

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The sequence complexity of exons trapped from the mouse genome. Nehls M, et al. Curr Biol, 1994 Nov 1. PMID 7874497
  2. A new beat for the SNARE drum. Götte M, et al. Trends Cell Biol, 1998 Jun. PMID 9695844
  3. Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria. Chen D, et al. J Biol Chem, 2001 Apr 20. PMID 11278501
  4. Seven novel mammalian SNARE proteins localize to distinct membrane compartments. Advani RJ, et al. J Biol Chem, 1998 Apr 24. PMID 9553086
  5. PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. Lin SS, et al. J Biol Chem, 2006 Aug 11. PMID 16717086

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables soluble NSF attachment protein activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in myelin sheath HDA PubMed 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
gamma-soluble NSF attachment protein
Names
N-ethylmaleimide-sensitive factor attachment protein gamma
SNAP-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419376.1 → NP_001406305.1  gamma-soluble NSF attachment protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140554
    Related
    ENSMUSP00000122681.2, ENSMUST00000150267.2

  2. NM_001419381.1 → NP_001406310.1  gamma-soluble NSF attachment protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC140554
    UniProtKB/TrEMBL
    A0A494BAE3
    Related
    ENSMUSP00000158047.2, ENSMUST00000235372.2

  3. NM_028017.2 → NP_082293.1  gamma-soluble NSF attachment protein isoform 1

    See identical proteins and their annotated locations for NP_082293.1

    Status: VALIDATED

    Source sequence(s)
    AC140554
    Consensus CDS
    CCDS29295.1
    UniProtKB/Swiss-Prot
    Q3TPT4, Q9CWZ7
    UniProtKB/TrEMBL
    Q8C1T5
    Related
    ENSMUSP00000025474.7, ENSMUST00000025474.14
    Conserved Domains (1) summary
    cd15832
    Location:8 → 278
    SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    63110910..63132521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246809.4 → XP_011245111.1  gamma-soluble NSF attachment protein isoform X3

    See identical proteins and their annotated locations for XP_011245111.1

    UniProtKB/TrEMBL
    A0A494BA20
    Conserved Domains (2) summary
    cd15832
    Location:24 → 59
    SNAP; TPR repeat [structural motif]
    cl24038
    Location:5 → 241
    SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

  2. XM_011246807.3 → XP_011245109.1  gamma-soluble NSF attachment protein isoform X2

    UniProtKB/TrEMBL
    A0A494BA20
    Conserved Domains (2) summary
    cd15832
    Location:29 → 64
    SNAP; TPR repeat [structural motif]
    cl24038
    Location:1 → 246
    SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

  3. XM_011246808.4 → XP_011245110.1  gamma-soluble NSF attachment protein isoform X3

    See identical proteins and their annotated locations for XP_011245110.1

    UniProtKB/TrEMBL
    A0A494BA20
    Conserved Domains (2) summary
    cd15832
    Location:24 → 59
    SNAP; TPR repeat [structural motif]
    cl24038
    Location:5 → 241
    SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWZ7.1 GenPept UniProtKB/Swiss-Prot:Q9CWZ7

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