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Tmbim6 transmembrane BAX inhibitor motif containing 6 [ Mus musculus (house mouse) ]

Gene ID: 110213, updated on 8-May-2024

Summary

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Official Symbol
Tmbim6provided by MGI
Official Full Name
transmembrane BAX inhibitor motif containing 6provided by MGI
Primary source
MGI:MGI:99682
See related
Ensembl:ENSMUSG00000023010 AllianceGenome:MGI:99682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bi1; Tegt; 5031406P05Rik
Summary
Enables endoribonuclease inhibitor activity and enzyme binding activity. Involved in cellular response to unfolded protein; negative regulation of RNA metabolic process; and negative regulation of immunoglobulin production. Acts upstream of or within endoplasmic reticulum calcium ion homeostasis; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Is expressed in head and retina. Orthologous to human TMBIM6 (transmembrane BAX inhibitor motif containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 555.8), liver adult (RPKM 490.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tmbim6 in Genome Data Viewer
Location:
15 F1; 15 56.13 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99290828..99307930)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99392947..99410049)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 186, member B Neighboring gene pre-mRNA processing factor 40B Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:99163430-99163646 Neighboring gene formin-like 3 Neighboring gene STARR-seq mESC enhancer starr_39705 Neighboring gene STARR-positive B cell enhancer ABC_E9923 Neighboring gene STARR-positive B cell enhancer ABC_E3156 Neighboring gene predicted gene, 22951 Neighboring gene STARR-positive B cell enhancer ABC_E761 Neighboring gene VISTA enhancer mm1635 Neighboring gene NCK-associated protein 5-like Neighboring gene NCK-associated protein 5-like, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E5516 Neighboring gene BCDIN3 domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Bax inhibitor-1 deficiency leads to obesity by increasing Ca(2+)-dependent insulin secretion. Philippaert K, et al. J Mol Med (Berl), 2020 Jun. PMID 32394396, Free PMC Article
  2. BI1 alleviates cardiac microvascular ischemia-reperfusion injury via modifying mitochondrial fission and inhibiting XO/ROS/F-actin pathways. Zhou H, et al. J Cell Physiol, 2019 Apr. PMID 30256421
  3. BAX inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival. Lisak D, et al. Cell Death Differ, 2016 Feb. PMID 26470731, Free PMC Article
  4. The protective role of Bax inhibitor-1 against chronic mild stress through the inhibition of monoamine oxidase A. Lee HY, et al. Sci Rep, 2013 Dec 2. PMID 24292328, Free PMC Article
  5. Bax inhibitor-1 enhances survival and neuronal differentiation of embryonic stem cells via differential regulation of mitogen-activated protein kinases activities. Jeon K, et al. Biochim Biophys Acta, 2012 Dec. PMID 22906541

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway].
    Title: [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway].
  2. TMBIM6 deficiency leads to bone loss by accelerating osteoclastogenesis.
    Title: TMBIM6 deficiency leads to bone loss by accelerating osteoclastogenesis.
  3. Transmembrane BAX inhibitor motif containing 6 suppresses presenilin-2 to preserve mitochondrial integrity after myocardial ischemia-reperfusion injury.
    Title: Transmembrane BAX inhibitor motif containing 6 suppresses presenilin-2 to preserve mitochondrial integrity after myocardial ischemia-reperfusion injury.
  4. TMBIM6 prevents VDAC1 multimerization and improves mitochondrial quality control to reduce sepsis-related myocardial injury.
    Title: TMBIM6 prevents VDAC1 multimerization and improves mitochondrial quality control to reduce sepsis-related myocardial injury.
  5. TMBIM6 promotes diabetic tubular epithelial cell survival and albumin endocytosis by inhibiting the endoplasmic reticulum stress sensor, IRE1alpha.
    Title: TMBIM6 promotes diabetic tubular epithelial cell survival and albumin endocytosis by inhibiting the endoplasmic reticulum stress sensor, IRE1α.
  6. [Bax inhibitor 1 inhibits vascular calcification in mice by activating optic atrophy 1 expression].
    Title: [Bax inhibitor 1 inhibits vascular calcification in mice by activating optic atrophy 1 expression].
  7. BI-1 ameliorates myocardial injury by activating the mitochondrial unfolded protein response and FUNDC1-related mitophagy in cardiorenal syndrome type 3.
    Title: BI-1 ameliorates myocardial injury by activating the mitochondrial unfolded protein response and FUNDC1-related mitophagy in cardiorenal syndrome type 3.
  8. TMBIM6 regulates redox-associated posttranslational modifications of IRE1alpha and ER stress response failure in aging mice and humans.
    Title: TMBIM6 regulates redox-associated posttranslational modifications of IRE1α and ER stress response failure in aging mice and humans.
  9. Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress.
    Title: Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress.
  10. Bax inhibitor-1 deficiency leads to obesity by increasing Ca(2+)-dependent insulin secretion.
    Title: Bax inhibitor-1 deficiency leads to obesity by increasing Ca(2+)-dependent insulin secretion.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endoribonuclease inhibitor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables endoribonuclease inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to unfolded protein IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to unfolded protein ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endoplasmic reticulum calcium ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of endoribonuclease activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of endoribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to L-glutamate ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bax inhibitor 1
Names
BI-1
testis enhanced gene transcript
testis-enhanced gene transcript protein
transmembrane BAX inhibitor motif-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171034.1 → NP_001164505.1  bax inhibitor 1

    See identical proteins and their annotated locations for NP_001164505.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AK036782, AK139901, BE990530, BY272301, CD554385
    Consensus CDS
    CCDS37201.1
    UniProtKB/Swiss-Prot
    Q3TX81, Q8BFY4, Q9D2C7
    UniProtKB/TrEMBL
    E0CX98
    Related
    ENSMUSP00000125563.2, ENSMUST00000161250.8
    Conserved Domains (1) summary
    cd10430
    Location:16 → 228
    BI-1; BAX inhibitor (BI)-1

  2. NM_001171035.1 → NP_001164506.1  bax inhibitor 1

    See identical proteins and their annotated locations for NP_001164506.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AK036782, AK139901, BE990530, BY158276, BY753376
    Consensus CDS
    CCDS37201.1
    UniProtKB/Swiss-Prot
    Q3TX81, Q8BFY4, Q9D2C7
    UniProtKB/TrEMBL
    E0CX98
    Related
    ENSMUSP00000125117.2, ENSMUST00000159209.8
    Conserved Domains (1) summary
    cd10430
    Location:16 → 228
    BI-1; BAX inhibitor (BI)-1

  3. NM_001171036.1 → NP_001164507.1  bax inhibitor 1

    See identical proteins and their annotated locations for NP_001164507.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AC118646, AK036782, AK139901, BE990530, BY272301
    Consensus CDS
    CCDS37201.1
    UniProtKB/Swiss-Prot
    Q3TX81, Q8BFY4, Q9D2C7
    UniProtKB/TrEMBL
    E0CX98
    Related
    ENSMUSP00000124651.2, ENSMUST00000160635.8
    Conserved Domains (1) summary
    cd10430
    Location:16 → 228
    BI-1; BAX inhibitor (BI)-1

  4. NM_026669.4 → NP_080945.1  bax inhibitor 1

    See identical proteins and their annotated locations for NP_080945.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AK036782, AK139901, BE990530, BY272301
    Consensus CDS
    CCDS37201.1
    UniProtKB/Swiss-Prot
    Q3TX81, Q8BFY4, Q9D2C7
    UniProtKB/TrEMBL
    E0CX98
    Related
    ENSMUSP00000023749.9, ENSMUST00000023749.15
    Conserved Domains (1) summary
    cd10430
    Location:16 → 228
    BI-1; BAX inhibitor (BI)-1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    99290828..99307930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159068.1 → XP_036014961.1  bax inhibitor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3TX81, Q8BFY4, Q9D2C7
    UniProtKB/TrEMBL
    E0CX98
    Conserved Domains (1) summary
    cd10430
    Location:16 → 228
    BI-1; BAX inhibitor (BI)-1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2C7.1 GenPept UniProtKB/Swiss-Prot:Q9D2C7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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