Pmch pro-melanin-concentrating hormone [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pmchprovided by MGI
Official Full Name: pro-melanin-concentrating hormoneprovided by MGI
Primary source: MGI:MGI:97629
See related: Ensembl:ENSMUSG00000035383 AllianceGenome:MGI:97629
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A230109K23Rik
Summary: This gene encodes a preproprotein that is cleaved to produce three mature peptides: melanin concentrating hormone, neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). The proprotein is processed differently depending on the tissue where it is expressed. Melanin concentrating hormone is involved in the regulation of food intake, energy homeostasis, and sleep-wake behavior. Disruption of this gene is associated with resistance to diet-induced obesity. [provided by RefSeq, May 2013]
Expression: Biased expression in liver E14 (RPKM 3.2), liver E14.5 (RPKM 3.0) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 43.7 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (87926934..87928236)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (88091072..88092374)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of hypothalamic MCH decreases food intake in amyotrophic lateral sclerosis.
Title: Loss of hypothalamic MCH decreases food intake in amyotrophic lateral sclerosis.
Melanin-concentrating hormone-producing neurons in the hypothalamus regulate brown adipose tissue and thus contribute to energy expenditure.
Title: Melanin-concentrating hormone-producing neurons in the hypothalamus regulate brown adipose tissue and thus contribute to energy expenditure.
Oxytocin-MCH circuit regulates monosynaptic inputs to MCH neurons and modulates social recognition memory.
Title: Oxytocin-MCH circuit regulates monosynaptic inputs to MCH neurons and modulates social recognition memory.
Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons.
Title: Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons.
Melanin-concentrating hormone neurons promote rapid eye movement sleep under normal circumstances.
Title: Melanin-concentrating hormone neurons contribute to dysregulation of rapid eye movement sleep in narcolepsy.
Glutamate in MCH neurons contributes to normal diurnal variability of REMs by regulating the levels of REMs during the dark period, but MCH neurons can promote REMs even in the absence of glutamate.
Title: Melanin-concentrating hormone neurons promote rapid eye movement sleep independent of glutamate release.
our experiments reveal an insulin-dependent activation of MCH neurons in obesity, which contributes via distinct mechanisms to the manifestation of impaired locomotor activity and insulin resistance.
Title: Insulin-Dependent Activation of MCH Neurons Impairs Locomotor Activity and Insulin Sensitivity in Obesity.
Results indicate that olanzapine reduced accumbens nucleus GABAergic transmission and that MCH is necessary for the hypolocomotor effects of olanzapine
Title: Melanin-concentrating hormone is necessary for olanzapine-inhibited locomotor activity in male mice.
The present work is the first study to systematically compare the effects of MCH signaling on behavioral and metabolic phenotypes.[meta-analysis]
Title: Meta-analysis of melanin-concentrating hormone signaling-deficient mice on behavioral and metabolic phenotypes.
A functional cross-talk between MCH and IL-10 prevents resolution of inflammation in experimental colitis.
Title: Inflammation-induced functional connectivity of melanin-concentrating hormone and IL-10.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Spontaneous (1) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pmch (e-PCR), detects polymorphism
- UniSTS:507162

AI503644 (e-PCR)
- UniSTS:164447

G73161 (e-PCR)
- UniSTS:231358

MARC_1391-1392:997375485:1 (e-PCR)
- UniSTS:231358

PMC199192P1 (e-PCR)
- UniSTS:271860

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables melanin-concentrating hormone activity	NAS Non-traceable Author Statement more info	PubMed
enables signaling receptor binding	NAS Non-traceable Author Statement more info	PubMed
enables type 1 melanin-concentrating hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 melanin-concentrating hormone receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in drinking behavior	ISO Inferred from Sequence Orthology more info
involved_in feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission, dopaminergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of circadian sleep/wake cycle, REM sleep	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pro-MCH

Names: neuropeptide-glutamic acid-isoleucine (NEI); neuropeptide-glycine-glutamic acid (NGE)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.