Adarb1 adenosine deaminase, RNA-specific, B1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adarb1provided by MGI
Official Full Name: adenosine deaminase, RNA-specific, B1provided by MGI
Primary source: MGI:MGI:891999
See related: Ensembl:ENSMUSG00000020262 AllianceGenome:MGI:891999
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Red1; Adar2; D10Bwg0447e; 1700057H01Rik
Summary: This gene encodes a double-stranded-RNA-specific adenosine deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression: Broad expression in cerebellum adult (RPKM 24.4), frontal lobe adult (RPKM 19.8) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (77126561..77254125, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (77290727..77418292, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The disruption of circadian rhythmicity of gene expression in the hippocampus and associated structures in Gria2[R/R] mice; a comparison with C57BL/6J and Adar2[-/-] mice strains.
Title: The disruption of circadian rhythmicity of gene expression in the hippocampus and associated structures in Gria2(R/R) mice; a comparison with C57BL/6J and Adar2(-/-) mice strains.
Pathological features of glial cells and motor neurons in the anterior horn of the spinal cord in sporadic ALS using ADAR2 conditional knockout mice.
Title: Pathological features of glial cells and motor neurons in the anterior horn of the spinal cord in sporadic ALS using ADAR2 conditional knockout mice.
Exercise-Induced ADAR2 Protects against Nonalcoholic Fatty Liver Disease through miR-34a.
Title: Exercise-Induced ADAR2 Protects against Nonalcoholic Fatty Liver Disease through miR-34a.
Heterogeneous RNA editing and influence of ADAR2 on mesothelioma chemoresistance and the tumor microenvironment.
Title: Heterogeneous RNA editing and influence of ADAR2 on mesothelioma chemoresistance and the tumor microenvironment.
that the mislocalization of ADAR2 in C9orf72 mediated amyotrophic lateral sclerosis/frontotemporal dementia is responsible for the alteration of RNA processing events that may impact vast cellular functions
Title: ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.
ADAR1 and ADAR2 are non-redundant and do not compensate for each other's essential functions in vivo.
Title: The majority of A-to-I RNA editing is not required for mammalian homeostasis.
ADAR2 plays a crucial role for light-induced phase-shift of the circadian clock.
Title: A-to-I RNA editing enzyme ADAR2 regulates light-induced circadian phase-shift.
PKCzeta/ADAR2 axis is a critical regulator of colorectal cancer metastases through modulation of miR-200 levels.
Title: The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer.
FMRP inhibits ADAR2 activity, absence of FMRP results in defects of RNA editing of neuronal mRNAs in the mouse model of Fragile X Syndrome.
Title: Absence of the Fragile X Mental Retardation Protein results in defects of RNA editing of neuronal mRNAs in mouse.
ADARB1 mediates adenosine to inosine RNA editing in the testis, and these editing events are dispensable for male fertility in an inbred mouse strain in the lab.
Title: Testicular adenosine to inosine RNA editing in the mouse is mediated by ADARB1.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224324

AW124433 (e-PCR)
- UniSTS:165702

Adarb1 (e-PCR), detects polymorphism
- UniSTS:479065

MDB0447 (e-PCR)
- UniSTS:125020

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

D10Bwg0424e (e-PCR), detects polymorphism
- UniSTS:141489

D10Bwg0447e (e-PCR), detects polymorphism
- UniSTS:141490

RH125148 (e-PCR)
- UniSTS:161970

UniSTS:259034 (e-PCR)
- UniSTS:259034

Adarb1 (e-PCR), detects polymorphism
- UniSTS:259034

RH125208 (e-PCR)
- UniSTS:162030

BB220382 (e-PCR)
- UniSTS:185841

D10Jhu56 (e-PCR), detects polymorphism
- UniSTS:158712

D10Jhu58 (e-PCR), detects polymorphism
- UniSTS:158714

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables adenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA adenosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA adenosine deaminase activity	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA adenosine deaminase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables tRNA-specific adenosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA processing	ISO Inferred from Sequence Orthology more info
involved_in RNA processing	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in adenosine to inosine editing	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenosine to inosine editing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenosine to inosine editing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenosine to inosine editing	ISO Inferred from Sequence Orthology more info
involved_in base conversion or substitution editing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within facial nerve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hypoglossal nerve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within innervation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA modification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within motor behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motor neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process controlling posture	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mRNA processing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord ventral commissure morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: double-stranded RNA-specific editase 1

Names: RNA-editing deaminase 1; RNA-editing enzyme 1; dsRNA adenosine deaminase

NP_001020008.1

EC 3.5.4.37

NP_001020009.1

EC 3.5.4.37

NP_570965.2

EC 3.5.4.37

XP_006513125.1

EC 3.5.4.37

XP_006513126.1

EC 3.5.4.37

XP_006513127.1

EC 3.5.4.37

XP_030100683.1

EC 3.5.4.37

XP_036011393.1

EC 3.5.4.37

XP_036011394.1

EC 3.5.4.37

XP_036011395.1

EC 3.5.4.37

XP_036011396.1

EC 3.5.4.37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024837.2 → NP_001020008.1 double-stranded RNA-specific editase 1 isoform 2

See identical proteins and their annotated locations for NP_001020008.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate, in-frame donor splice site at one of the internal coding exons, compared to transcript variant 1. This results in a longer isoform (2) containing a 10 aa segment that is missing in isoform 1.

Source sequence(s)

AF403107, BB622419, BC030049, BC040200

Consensus CDS

CCDS35948.1

UniProtKB/Swiss-Prot

Q3UHM7, Q8K3X1, Q91ZS6, Q91ZS7, Q91ZS8, Q91ZS9, Q99MU8

Related

ENSMUSP00000095976.3, ENSMUST00000098374.9

Conserved Domains (3) summary

smart00552
Location:322 → 708

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cd19895
Location:75 → 146

DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

cd19898
Location:232 → 301

DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
NM_001024838.2 → NP_001020009.1 double-stranded RNA-specific editase 1 isoform 3

Status: REVIEWED

Source sequence(s)

AK141777, AK164931, BC030049, BC040200, BY281644

Conserved Domains (3) summary

smart00552
Location:316 → 692

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cd19895
Location:69 → 140

DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

cd19898
Location:226 → 295

DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
NM_130895.3 → NP_570965.2 double-stranded RNA-specific editase 1 isoform 1

See identical proteins and their annotated locations for NP_570965.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the shorter isoform (1).

Source sequence(s)

AF291049, AF403107, BB622419, BC030049, BC040200

Consensus CDS

CCDS35949.1

UniProtKB/Swiss-Prot

Q91ZS8

Related

ENSMUSP00000020496.8, ENSMUST00000020496.14

Conserved Domains (3) summary

smart00552
Location:322 → 698

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cd19895
Location:75 → 146

DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

cd19898
Location:232 → 301

DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

RNA

NR_004429.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate, in-frame donor splice site at one of the internal coding exons, and results from an auto RNA editing event (AA->AI) that creates a novel acceptor splice site, splicing to which inserts 47 nt into the coding region, compared to transcript variant 1. This causes a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense-mediated mRNA decay (NMD). According to PMIDs:12459255 and 16382140, the RNA editing_induced_alternative splicing is observed at a frequency of 80% in mouse and serves to regulate Adarb1 protein expression and activity in vivo.

Source sequence(s)

AF403109, BB622419, BC030049, BC040200

Related

ENSMUST00000144547.8
NR_021486.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) results from an auto RNA editing event (AA->AI) that creates a novel acceptor splice site, splicing to which inserts 47 nt into the coding region, compared to transcript variant 1. This causes a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense-mediated mRNA decay (NMD). According to PMIDs:12459255 and 16382140, the RNA editing_induced_alternative splicing is observed at a frequency of 80% in mouse and serves to regulate Adarb1 protein expression and activity in vivo.

Source sequence(s)

AF403108, BC030049, BC040200, CJ115965

Related

ENSMUST00000105404.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

77126561..77254125 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513064.3 → XP_006513127.1 double-stranded RNA-specific editase 1 isoform X4

Conserved Domains (3) summary

smart00552
Location:316 → 702

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cd19895
Location:69 → 140

DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

cd19898
Location:226 → 295

DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
XM_036155500.1 → XP_036011393.1 double-stranded RNA-specific editase 1 isoform X3

UniProtKB/Swiss-Prot

Q3UHM7, Q8K3X1, Q91ZS6, Q91ZS7, Q91ZS8, Q91ZS9, Q99MU8

Conserved Domains (3) summary

smart00552
Location:322 → 708

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cd19895
Location:75 → 146

DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

cd19898
Location:232 → 301

DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
XM_036155501.1 → XP_036011394.1 double-stranded RNA-specific editase 1 isoform X3

UniProtKB/Swiss-Prot

Q3UHM7, Q8K3X1, Q91ZS6, Q91ZS7, Q91ZS8, Q91ZS9, Q99MU8

Conserved Domains (3) summary

smart00552
Location:322 → 708

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cd19895
Location:75 → 146

DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

cd19898
Location:232 → 301

DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
XM_030244823.2 → XP_030100683.1 double-stranded RNA-specific editase 1 isoform X3

UniProtKB/Swiss-Prot

Q3UHM7, Q8K3X1, Q91ZS6, Q91ZS7, Q91ZS8, Q91ZS9, Q99MU8

Conserved Domains (3) summary

smart00552
Location:322 → 708

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cd19895
Location:75 → 146

DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

cd19898
Location:232 → 301

DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
XM_006513063.4 → XP_006513126.1 double-stranded RNA-specific editase 1 isoform X2

Conserved Domains (3) summary

smart00552
Location:386 → 762

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cd19895
Location:139 → 210

DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

cd19898
Location:296 → 365

DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
XM_006513062.4 → XP_006513125.1 double-stranded RNA-specific editase 1 isoform X1

Conserved Domains (3) summary

smart00552
Location:386 → 772

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cd19895
Location:139 → 210

DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

cd19898
Location:296 → 365

DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
XM_036155503.1 → XP_036011396.1 double-stranded RNA-specific editase 1 isoform X4

Conserved Domains (3) summary

smart00552
Location:316 → 702

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cd19895
Location:69 → 140

DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

cd19898
Location:226 → 295

DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
XM_036155502.1 → XP_036011395.1 double-stranded RNA-specific editase 1 isoform X3

UniProtKB/Swiss-Prot

Q3UHM7, Q8K3X1, Q91ZS6, Q91ZS7, Q91ZS8, Q91ZS9, Q99MU8

Conserved Domains (3) summary

smart00552
Location:322 → 708

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cd19895
Location:75 → 146

DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

cd19898
Location:232 → 301

DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001024839.1: Suppressed sequence

Description

NM_001024839.1: This RefSeq, based on a downstream AUG, was permanently suppressed because use of the in-frame upstream AUG, with a strong Kozak signal, would render the transcript susceptible to nonsense-mediated decay.
NM_001024840.1: Suppressed sequence

Description

NM_001024840.1: This RefSeq, based on a downstream AUG, was permanently suppressed because use of the in-frame upstream AUG, with a strong Kozak signal, would render the transcript susceptible to nonsense-mediated decay.