Rps6ka3 ribosomal protein S6 kinase polypeptide 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rps6ka3provided by MGI
Official Full Name: ribosomal protein S6 kinase polypeptide 3provided by MGI
Primary source: MGI:MGI:104557
See related: Ensembl:ENSMUSG00000031309 AllianceGenome:MGI:104557
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rsk2; MPK-9; p90RSK3; pp90RSK2; MAPKAPK-1b; S6K-alpha3
Summary: Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in response to lipopolysaccharide and toll-like receptor signaling pathway. Predicted to be located in cytosol and nucleolus. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including alimentary system; blastocyst; branchial arch; central nervous system; and eye. Used to study Coffin-Lowry syndrome. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability 19. Orthologous to human RPS6KA3 (ribosomal protein S6 kinase A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 6.8), genital fat pad adult (RPKM 5.9) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F4; X 73.27 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (158038652..158151240)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (159255665..159368244)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RSK2 inactivation cooperates with AXIN1 inactivation or beta-catenin activation to promote hepatocarcinogenesis.
Title: RSK2 inactivation cooperates with AXIN1 inactivation or β-catenin activation to promote hepatocarcinogenesis.
The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems.
Title: The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems.
Ribosomal S6 Protein Kinase 2 Aggravates the Process of Systemic Scleroderma.
Title: Ribosomal S6 Protein Kinase 2 Aggravates the Process of Systemic Scleroderma.
RSK-3 promotes cartilage regeneration via interacting with rpS6 in cartilage stem/progenitor cells.
Title: RSK-3 promotes cartilage regeneration via interacting with rpS6 in cartilage stem/progenitor cells.
RSK2 Maintains Adult Estrogen Homeostasis by Inhibiting ERK1/2-Mediated Degradation of Estrogen Receptor Alpha.
Title: RSK2 Maintains Adult Estrogen Homeostasis by Inhibiting ERK1/2-Mediated Degradation of Estrogen Receptor Alpha.
RSK2 mediates a procontractile signaling pathway that contributes to the regulation of basal vascular tone, myogenic vasoconstriction, and blood pressure
Title: RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na(+)/H(+) exchanger.
Severe deficits were identified in spatial pattern separation in an Rsk2-deficient model of Coffin-Lowry syndrome.
Title: Selective alteration of adult hippocampal neurogenesis and impaired spatial pattern separation performance in the RSK2-deficient mouse model of Coffin-Lowry syndrome.
IL-10 induction in B cells was regulated by an ERK1/2- and p90 ribosomal S6 kinase-dependent mechanism, unlike in macrophages in which p90 ribosomal S6 kinase was not required.
Title: Differential control of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases.
Rsk1 and Rsk2 protein levels are specifically reduced in the striatum of Huntington's disease mouse models at symptomatic stage.
Title: Loss of striatal 90-kDa ribosomal S6 kinase (Rsk) is a key factor for motor, synaptic and transcription dysfunction in Huntington's disease.
M-CSF-evoked ERK1/2 activation was decreased, whereas AKT activation was enhanced in SHP2-deficient BMMs. ERK1/2, via its downstream target RSK2, mediates this negative feedback by negatively regulating phosphorylation of M-CSF receptor at Tyr721 and, consequently, its binding to p85 subunit of PI3K and PI3K activation.
Title: A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:238103

A010B08 (e-PCR)
- UniSTS:20785

DXMit70 (e-PCR), detects polymorphism
- UniSTS:132176

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribosomal protein S6 kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in toll-like receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribosomal protein S6 kinase alpha-3

Names: 90 kDa ribosomal protein S6 kinase 3; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; ribosomal protein S6 kinase 2

NP_001333604.1

EC 2.7.11.1

NP_683747.1

EC 2.7.11.1

XP_006528750.1

EC 2.7.11.1

XP_006528751.1

EC 2.7.11.1

XP_017173843.1

EC 2.7.11.1

XP_017173844.1

EC 2.7.11.1

XP_030107056.1

EC 2.7.11.1

XP_030107058.1

EC 2.7.11.1

XP_036017675.1

EC 2.7.11.1

XP_036017676.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346675.1 → NP_001333604.1 ribosomal protein S6 kinase alpha-3 isoform 2

Status: VALIDATED

Source sequence(s)

AL808146

Consensus CDS

CCDS85822.1

UniProtKB/TrEMBL

A7E215, B1AXN9

Conserved Domains (2) summary

cd05582
Location:44 → 360

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14176
Location:374 → 712

STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
NM_148945.2 → NP_683747.1 ribosomal protein S6 kinase alpha-3 isoform 1

See identical proteins and their annotated locations for NP_683747.1

Status: VALIDATED

Source sequence(s)

AL808146, AY083469, BC038683, CJ123041

Consensus CDS

CCDS30502.1

UniProtKB/Swiss-Prot

B1AXN4, P18654, Q03140, Q8K3J8

UniProtKB/TrEMBL

A7E215

Related

ENSMUSP00000033671.7, ENSMUST00000033671.13

Conserved Domains (2) summary

cd05582
Location:72 → 388

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14176
Location:402 → 740

STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

158038652..158151240

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318355.3 → XP_017173844.1 ribosomal protein S6 kinase alpha-3 isoform X2

UniProtKB/TrEMBL

A7E215, B1AXN9

Conserved Domains (2) summary

cd05582
Location:44 → 360

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14176
Location:374 → 712

STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
XM_030251196.2 → XP_030107056.1 ribosomal protein S6 kinase alpha-3 isoform X2

UniProtKB/TrEMBL

A7E215, B1AXN9

Related

ENSMUSP00000108112.2, ENSMUST00000112493.8

Conserved Domains (2) summary

cd05582
Location:44 → 360

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14176
Location:374 → 712

STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
XM_030251198.2 → XP_030107058.1 ribosomal protein S6 kinase alpha-3 isoform X2

UniProtKB/TrEMBL

A7E215, B1AXN9

Conserved Domains (2) summary

cd05582
Location:44 → 360

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14176
Location:374 → 712

STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
XM_036161782.1 → XP_036017675.1 ribosomal protein S6 kinase alpha-3 isoform X1

UniProtKB/TrEMBL

A7E215

Conserved Domains (2) summary

cd05582
Location:51 → 367

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14176
Location:381 → 719

STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
XM_006528687.3 → XP_006528750.1 ribosomal protein S6 kinase alpha-3 isoform X2

See identical proteins and their annotated locations for XP_006528750.1

UniProtKB/TrEMBL

A7E215, B1AXN9

Conserved Domains (2) summary

cd05582
Location:44 → 360

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14176
Location:374 → 712

STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
XM_017318354.3 → XP_017173843.1 ribosomal protein S6 kinase alpha-3 isoform X2

UniProtKB/TrEMBL

A7E215, B1AXN9

Conserved Domains (2) summary

cd05582
Location:44 → 360

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14176
Location:374 → 712

STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
XM_036161783.1 → XP_036017676.1 ribosomal protein S6 kinase alpha-3 isoform X2

UniProtKB/TrEMBL

A7E215, B1AXN9

Conserved Domains (2) summary

cd05582
Location:44 → 360

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14176
Location:374 → 712

STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
XM_006528688.4 → XP_006528751.1 ribosomal protein S6 kinase alpha-3 isoform X3

See identical proteins and their annotated locations for XP_006528751.1

UniProtKB/TrEMBL

A7E215

Conserved Domains (2) summary

cd05582
Location:43 → 359

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14176
Location:373 → 711

STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)