Cds2 CDP-diacylglycerol synthase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cds2provided by MGI
Official Full Name: CDP-diacylglycerol synthase 2provided by MGI
Primary source: MGI:MGI:1332236
See related: Ensembl:ENSMUSG00000058793 AllianceGenome:MGI:1332236
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D2Wsu127e; 5730450N06Rik; 5730460C18Rik
Summary: Predicted to enable phosphatidate cytidylyltransferase activity. Involved in lipid droplet formation. Located in endoplasmic reticulum. Is expressed in several structures, including central nervous system; immune system; retina; skin; and testis. Orthologous to human CDS2 (CDP-diacylglycerol synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cerebellum adult (RPKM 33.8), frontal lobe adult (RPKM 33.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F2; 2 64.15 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (132105068..132153970)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (132253338..132312050)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic CDP-diacylglycerol synthase 2 deficiency causes mitochondrial dysfunction and promotes rapid progression of NASH and fibrosis.
Title: Hepatic CDP-diacylglycerol synthase 2 deficiency causes mitochondrial dysfunction and promotes rapid progression of NASH and fibrosis.
Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition.
Title: Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition.
Cds2 showed a ubiquitous pattern of expression and was mapped to chromosome 2G1.
Title: Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI854580 (e-PCR)
- UniSTS:178712

RH125721 (e-PCR)
- UniSTS:142369

NoName (e-PCR)
- UniSTS:234529

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidate cytidylyltransferase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidate cytidylyltransferase activity	NAS Non-traceable Author Statement more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CDP-diacylglycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glycosylation	NAS Non-traceable Author Statement more info	PubMed
involved_in lipid droplet formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid droplet formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phototransduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	NAS Non-traceable Author Statement more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidate cytidylyltransferase 2

Names: CDP-DAG synthase 2; CDP-DG synthase 2; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2; CDP-diglyceride pyrophosphorylase 2; CDP-diglyceride synthase 2; CTP:phosphatidate cytidylyltransferase 2

NP_001277968.1

EC 2.7.7.41

NP_001277969.1

EC 2.7.7.41

NP_619592.1

EC 2.7.7.41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291039.1 → NP_001277968.1 phosphatidate cytidylyltransferase 2 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

AI854580, AK017677, AK049257, AK147541, BQ572878, CD351907, CD540005

Consensus CDS

CCDS71150.1

UniProtKB/TrEMBL

A2AMQ5, Q8BX08

Related

ENSMUSP00000086886.5, ENSMUST00000089461.11

Conserved Domains (1) summary

cl21502
Location:88 → 407

CTP_transf_1; Cytidylyltransferase family
NM_001291040.1 → NP_001277969.1 phosphatidate cytidylyltransferase 2 isoform c

See identical proteins and their annotated locations for NP_001277969.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AK050589, BU610248, CJ112406

Consensus CDS

CCDS79850.1

UniProtKB/TrEMBL

Q6PBC0

Related

ENSMUSP00000105786.2, ENSMUST00000110158.8

Conserved Domains (2) summary

pfam04718
Location:44 → 86

ATP-synt_G; Mitochondrial ATP synthase g subunit

cl21502
Location:69 → 129

CTP_transf_1; Cytidylyltransferase family
NM_138651.7 → NP_619592.1 phosphatidate cytidylyltransferase 2 isoform a

See identical proteins and their annotated locations for NP_619592.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AI854580, AK017677, AK147541, BQ572878, CD351907, CJ112406

Consensus CDS

CCDS16772.1

UniProtKB/Swiss-Prot

Q3TMD1, Q6NSU1, Q99L43

UniProtKB/TrEMBL

Q8BX08

Related

ENSMUSP00000099470.5, ENSMUST00000103181.11

Conserved Domains (1) summary

cl21502
Location:105 → 424

CTP_transf_1; Cytidylyltransferase family