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Csnk1a1 casein kinase 1, alpha 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 113927, updated on 2-May-2024

Summary

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Official Symbol
Csnk1a1provided by RGD
Official Full Name
casein kinase 1, alpha 1provided by RGD
Primary source
RGD:71098
See related
Ensembl:ENSRNOG00000063313 AllianceGenome:RGD:71098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CK1
Summary
Enables several functions, including ATP binding activity; magnesium ion binding activity; and phosphoprotein binding activity. Involved in peptidyl-serine phosphorylation and response to morphine. Located in cytosol and nuclear speck. Orthologous to human CSNK1A1 (casein kinase 1 alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 1262.5), Lung (RPKM 1169.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
18q12.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (57285156..57320540)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (55017049..55050184)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (56887722..56910610)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene Rho guanine nucleotide exchange factor 37 Neighboring gene ribosomal protein S23, pseudogene 2 Neighboring gene microRNA 145 Neighboring gene cardiac mesoderm enhancer-associated non-coding RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Opioid receptor agonists enhance the phosphorylation state of Fas-associated death domain (FADD) protein in the rat brain: functional interactions with casein kinase Ialpha, Galpha(i) proteins, and ERK1/2 signaling. García-Fuster MJ, et al. Neuropharmacology, 2008 Oct. PMID 18657552
  2. Casein kinase 1 alpha associates with the tau-bearing lesions of inclusion body myositis. Kannanayakal TJ, et al. Neurosci Lett, 2008 Jan 31. PMID 18191026, Free PMC Article
  3. Casein kinase I alpha and alpha L: alternative splicing-generated kinases exhibit different catalytic properties. Zhang J, et al. Biochemistry, 1996 Dec 17. PMID 8973207
  4. The casein kinase Ialpha isoform is both physically positioned and functionally competent to regulate multiple events of mRNA metabolism. Gross SD, et al. J Cell Sci, 1999 Aug. PMID 10413673
  5. A new molecular link between the fibrillar and granulovacuolar lesions of Alzheimer's disease. Ghoshal N, et al. Am J Pathol, 1999 Oct. PMID 10514399, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CK1 associates with and phosphorylates REST at two neighboring, but distinct, motifs within the C terminus of REST critical for binding of beta-TrCP and targeting of REST for proteasomal degradation.
    Title: Casein kinase 1 suppresses activation of REST in insulted hippocampal neurons and halts ischemia-induced neuronal death.
  2. Data show that Golgi apparatus casein kinase (G-CK) catalyzes the phosphorylation of rhBMP-15 and rhGDF-9.
    Title: Golgi apparatus casein kinase phosphorylates bioactive Ser-6 of bone morphogenetic protein 15 and growth and differentiation factor 9.
  3. These data indicate that CKIalpha, PIPKIalpha, and Star-PAP function together to modulate the production of specific Star-PAP messages.
    Title: CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC156603

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoprotein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IEA
Inferred from Electronic Annotation
more info
  
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to nutrient IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to nutrient ISO
Inferred from Sequence Orthology
more info
  
involved_in intermediate filament cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in intermediate filament cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intermediate filament cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of NLRP3 inflammasome complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IC
Inferred by Curator
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of beta-catenin destruction complex IEA
Inferred from Electronic Annotation
more info
  
part_of beta-catenin destruction complex ISO
Inferred from Sequence Orthology
more info
  
part_of beta-catenin destruction complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
  
located_in keratin filament ISO
Inferred from Sequence Orthology
more info
  
located_in keratin filament ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex IEA
Inferred from Electronic Annotation
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex ISO
Inferred from Sequence Orthology
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
casein kinase I isoform alpha; casein kinase I
Names
CKI-alpha
NP_446067.2
XP_038952461.1
XP_038952463.1
XP_038952464.1
XP_038952465.1
XP_038952466.1
XP_038952469.1
XP_063133122.1
XP_063133123.1
XP_063133124.1
XP_063133125.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053615.2 → NP_446067.2  casein kinase I isoform alpha

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0JPL2, A6IXH5
    Conserved Domains (1) summary
    cd14128
    Location:16 → 281
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    57285156..57320540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277055.1 → XP_063133125.1  casein kinase I isoform X8

    UniProtKB/TrEMBL
    D3ZRE3

  2. XM_039096538.2 → XP_038952466.1  casein kinase I isoform X6

    UniProtKB/TrEMBL
    A6IXH5
    Conserved Domains (1) summary
    cd14128
    Location:16 → 281
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

  3. XM_063277054.1 → XP_063133124.1  casein kinase I isoform X7

  4. XM_039096541.2 → XP_038952469.1  casein kinase I isoform X9

    UniProtKB/Swiss-Prot
    P97633, P97634
    UniProtKB/TrEMBL
    A6IXH7
    Related
    ENSRNOP00000082592.1
    Conserved Domains (1) summary
    cd14128
    Location:16 → 281
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

  5. XM_063277052.1 → XP_063133122.1  casein kinase I isoform X1

  6. XM_063277053.1 → XP_063133123.1  casein kinase I isoform X2

  7. XM_039096535.2 → XP_038952463.1  casein kinase I isoform X3

    UniProtKB/TrEMBL
    A6IXH5
    Related
    ENSRNOP00000085265.1
    Conserved Domains (1) summary
    cd14128
    Location:16 → 309
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

  8. XM_039096536.2 → XP_038952464.1  casein kinase I isoform X4

    UniProtKB/Swiss-Prot
    P97633, P97634
    Conserved Domains (1) summary
    cd14128
    Location:16 → 309
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

  9. XM_039096537.2 → XP_038952465.1  casein kinase I isoform X5

    UniProtKB/Swiss-Prot
    P97633, P97634
    Conserved Domains (1) summary
    cd14128
    Location:16 → 309
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

  10. XM_039096533.2 → XP_038952461.1  casein kinase I isoform X1

    UniProtKB/TrEMBL
    A6IXH5
    Conserved Domains (1) summary
    cd14128
    Location:16 → 309
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97633.1 GenPept UniProtKB/Swiss-Prot:P97633

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