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Banf1 BAF nuclear assembly factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114087, updated on 30-Mar-2024

Summary

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Official Symbol
Banf1provided by RGD
Official Full Name
BAF nuclear assembly factor 1provided by RGD
Primary source
RGD:620662
See related
Ensembl:ENSRNOG00000020460 AllianceGenome:RGD:620662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Baf; Bcrp1; L2bp1; L2bp1/Baf
Summary
Enables identical protein binding activity. Predicted to be involved in chromosome condensation; chromosome segregation; and negative regulation of viral genome replication. Predicted to act upstream of or within DNA integration. Located in condensed chromosome and nucleus. Human ortholog(s) of this gene implicated in progeria. Orthologous to human BANF1 (BAF nuclear assembly factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 474.6), Heart (RPKM 389.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Banf1 in Genome Data Viewer
Location:
1q43
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212101523..212103568, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202672170..202674215, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (220744195..220746224, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cation channel, sperm associated 1 Neighboring gene cystatin E/M Neighboring gene eukaryotic translation initiation factor 1A domain containing Neighboring gene spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural basis for DNA bridging by barrier-to-autointegration factor. Bradley CM, et al. Nat Struct Mol Biol, 2005 Oct. PMID 16155580
  2. Barrier to autointegration factor 1, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3, and splicing factor 3b subunit 4 as early-stage cancer decision markers and drivers of hepatocellular carcinoma. Shen Q, et al. Hepatology, 2018 Apr. PMID 29059470
  3. Poxviral B1 kinase overcomes barrier to autointegration factor, a host defense against virus replication. Wiebe MS, et al. Cell Host Microbe, 2007 May 17. PMID 18005698, Free PMC Article
  4. LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly. Dechat T, et al. J Cell Sci, 2004 Dec 1. PMID 15546916
  5. A previously unidentified host protein protects retroviral DNA from autointegration. Lee MS, et al. Proc Natl Acad Sci U S A, 1998 Feb 17. PMID 9465049, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly
    Title: LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105365

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA integration ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin organization ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic nuclear membrane reassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic nuclear membrane reassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cGAS/STING signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type I interferon production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in condensed chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in condensed chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
barrier-to-autointegration factor
Names
Breakpoint cluster region protein, uterine leiomyoma, 1
Breakpoint cluster region protein, uterine leiomyoma, 1; barrier to autointegration factor
LAP2-binding protein 1
Lap2 binding protein 1
barrier to autointegration factor 1
breakpoint cluster region protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053631.3 → NP_446083.1  barrier-to-autointegration factor

    See identical proteins and their annotated locations for NP_446083.1

    Status: VALIDATED

    Source sequence(s)
    BC084726, CB766065, JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q9R1T1
    Related
    ENSRNOP00000027734.3, ENSRNOT00000027734.6
    Conserved Domains (1) summary
    pfam02961
    Location:1 → 86
    BAF; Barrier to autointegration factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    212101523..212103568 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230631.3 → XP_006230693.1  barrier-to-autointegration factor isoform X1

    See identical proteins and their annotated locations for XP_006230693.1

    UniProtKB/Swiss-Prot
    Q9R1T1
    Conserved Domains (1) summary
    pfam02961
    Location:1 → 86
    BAF; Barrier to autointegration factor

  2. XM_039106718.2 → XP_038962646.1  barrier-to-autointegration factor isoform X1

    UniProtKB/Swiss-Prot
    Q9R1T1
    Conserved Domains (1) summary
    pfam02961
    Location:1 → 86
    BAF; Barrier to autointegration factor

  3. XM_006230630.5 → XP_006230692.1  barrier-to-autointegration factor isoform X1

    See identical proteins and their annotated locations for XP_006230692.1

    UniProtKB/Swiss-Prot
    Q9R1T1
    Conserved Domains (1) summary
    pfam02961
    Location:1 → 86
    BAF; Barrier to autointegration factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1T1.1 GenPept UniProtKB/Swiss-Prot:Q9R1T1

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