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Sardh sarcosine dehydrogenase [ Rattus norvegicus (Norway rat) ]

Gene ID: 114123, updated on 2-May-2024

Summary

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Symbol
Sardhprovided by RGD
Full Name
sarcosine dehydrogenaseprovided by RGD
Primary source
RGD:621125
See related
Ensembl:ENSRNOG00000006916 AllianceGenome:RGD:621125
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables flavin adenine dinucleotide binding activity; folic acid binding activity; and sarcosine dehydrogenase activity. Involved in tetrahydrofolate interconversion. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in sarcosinemia. Orthologous to human SARDH (sarcosine dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 535.2), Kidney (RPKM 324.8) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sardh in Genome Data Viewer
Location:
3p12
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (30908621..30973409, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (10510553..10575342, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (5737203..5802153, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486349 Neighboring gene dopamine beta-hydroxylase Neighboring gene uncharacterized LOC102548789 Neighboring gene vav guanine nucleotide exchange factor 2 Neighboring gene BRD3 opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and tissue distribution of rat sarcosine dehydrogenase. Bergeron F, et al. Eur J Biochem, 1998 Nov 1. PMID 9839943
  2. Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavoprotein nature and enzymatic properties of the purified proteins. Wittwer AJ, et al. J Biol Chem, 1981 Apr 25. PMID 6163778
  3. The amino acid sequences of the flavin-peptides of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver mitochondria. Cook RJ, et al. J Biol Chem, 1985 Oct 25. PMID 4055729
  4. Compartmentalization of Mammalian folate-mediated one-carbon metabolism. Tibbetts AS, et al. Annu Rev Nutr, 2010 Aug 21. PMID 20645850
  5. Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion. Cao Y, et al. J Proteome Res, 2019 May 3. PMID 30901224

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables folic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables sarcosine dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sarcosine dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sarcosine dehydrogenase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in choline catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in choline catabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in glycine biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in sarcosine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tetrahydrofolate interconversion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
sarcosine dehydrogenase, mitochondrial
NP_001409929.1
NP_446116.2
XP_006233793.1
XP_006233795.1
XP_038960018.1
XP_063139062.1
XP_063139063.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001423000.1 → NP_001409929.1  sarcosine dehydrogenase, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JTK8, F1LRY5

  2. NM_001429649.1 → NP_001416578.1  sarcosine dehydrogenase, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  3. NM_001429650.1 → NP_001416579.1  sarcosine dehydrogenase, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  4. NM_053664.3 → NP_446116.2  sarcosine dehydrogenase, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JTK8, F1LRY5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    30908621..30973409 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233733.5 → XP_006233795.1  sarcosine dehydrogenase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    O88499, Q64380
    UniProtKB/TrEMBL
    A6JTK8, F1LRY5
    Conserved Domains (3) summary
    COG0404
    Location:480 → 917
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:64 → 448
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam16350
    Location:431 → 486
    FAO_M; FAD dependent oxidoreductase central domain

  2. XM_006233731.5 → XP_006233793.1  sarcosine dehydrogenase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    O88499, Q64380
    UniProtKB/TrEMBL
    A6JTK8, F1LRY5
    Conserved Domains (3) summary
    COG0404
    Location:480 → 917
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:64 → 448
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam16350
    Location:431 → 486
    FAO_M; FAD dependent oxidoreductase central domain

  3. XM_063282992.1 → XP_063139062.1  sarcosine dehydrogenase, mitochondrial isoform X2

  4. XM_039104090.2 → XP_038960018.1  sarcosine dehydrogenase, mitochondrial isoform X2

    Conserved Domains (3) summary
    COG0665
    Location:64 → 448
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam16350
    Location:431 → 486
    FAO_M; FAD dependent oxidoreductase central domain
    cl39066
    Location:480 → 512
    GCV_T; Aminomethyltransferase folate-binding domain

  5. XM_063282993.1 → XP_063139063.1  sarcosine dehydrogenase, mitochondrial isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64380.2 GenPept UniProtKB/Swiss-Prot:Q64380

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