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Spata2 spermatogenesis associated 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114210, updated on 25-Apr-2024

Summary

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Official Symbol
Spata2provided by RGD
Official Full Name
spermatogenesis associated 2provided by RGD
Primary source
RGD:620754
See related
Ensembl:ENSRNOG00000009207 AllianceGenome:RGD:620754
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable signaling receptor complex adaptor activity and ubiquitin-specific protease binding activity. Predicted to be involved in several processes, including protein deubiquitination; regulation of necroptotic process; and regulation of tumor necrosis factor-mediated signaling pathway. Predicted to act upstream of or within seminiferous tubule development and spermatogenesis. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human SPATA2 (spermatogenesis associated 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 84.1), Thymus (RPKM 60.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Spata2 in Genome Data Viewer
Location:
3q42
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (176621974..176639784, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (156202962..156213283, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (164229211..164239483, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD22 Neighboring gene solute carrier family 9 member A8 Neighboring gene uncharacterized LOC134486208 Neighboring gene ring finger protein 114 Neighboring gene snail family transcriptional repressor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Spata2 Knockdown Exacerbates Brain Inflammation via NF-κB/P38MAPK Signaling and NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Rats. Ren Y, et al. Neurochem Res, 2021 Sep. PMID 34075523
  2. Evidence for FSH-dependent upregulation of SPATA2 (spermatogenesis-associated protein 2). Onisto M, et al. Biochem Biophys Res Commun, 2001 Apr 27. PMID 11322771
  3. cDNA cloning and characterization of PD1: a novel human testicular protein with different expressions in various testiculopathies. Graziotto R, et al. Exp Cell Res, 1999 May 1. PMID 10222154
  4. Deletion of Spata2 by CRISPR/Cas9n causes increased inhibin alpha expression and attenuated fertility in male mice. Zhao J, et al. Biol Reprod, 2017 Sep 1. PMID 29025062
  5. SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination. Wei R, et al. Genes Dev, 2017 Jun 1. PMID 28701375, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spata2 Knockdown Exacerbates Brain Inflammation via NF-kappaB/P38MAPK Signaling and NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Rats.
    Title: Spata2 Knockdown Exacerbates Brain Inflammation via NF-κB/P38MAPK Signaling and NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Rats.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC93291

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor complex adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-specific protease binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of necroptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein linear deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of necroptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of necroptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of tumor necrosis factor-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within seminiferous tubule development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
spermatogenesis-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429657.1 → NP_001416586.1  spermatogenesis-associated protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  2. NM_001429658.1 → NP_001416587.1  spermatogenesis-associated protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  3. NM_053675.3 → NP_446127.3  spermatogenesis-associated protein 2

    See identical proteins and their annotated locations for NP_446127.3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    F1LNA7, Q66HP6, Q91XS7
    Conserved Domains (1) summary
    cd19757
    Location:451 → 494
    Bbox1; B-box-type 1 zinc finger (Bbox1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    176621974..176639784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235636.5 → XP_006235698.1  spermatogenesis-associated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    F1LNA7, Q66HP6, Q91XS7
    Conserved Domains (1) summary
    cd19757
    Location:451 → 494
    Bbox1; B-box-type 1 zinc finger (Bbox1)

  2. XM_039104093.2 → XP_038960021.1  spermatogenesis-associated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    F1LNA7, Q66HP6, Q91XS7
    Conserved Domains (1) summary
    cd19757
    Location:451 → 494
    Bbox1; B-box-type 1 zinc finger (Bbox1)

  3. XM_039104092.2 → XP_038960020.1  spermatogenesis-associated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    F1LNA7, Q66HP6, Q91XS7
    Related
    ENSRNOP00000012604.4
    Conserved Domains (1) summary
    cd19757
    Location:451 → 494
    Bbox1; B-box-type 1 zinc finger (Bbox1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66HP6.1 GenPept UniProtKB/Swiss-Prot:Q66HP6

Gene LinkOut

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