Slc28a3 solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc28a3provided by MGI
Official Full Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 3provided by MGI
Primary source: MGI:MGI:2137361
See related: Ensembl:ENSMUSG00000021553 AllianceGenome:MGI:2137361
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cnt3
Summary: Enables purine-specific nucleoside:sodium symporter activity and pyrimidine- and adenine-specific:sodium symporter activity. Acts upstream of or within purine nucleoside transmembrane transport and pyrimidine nucleoside transport. Located in brush border membrane. Is expressed in pancreas. Orthologous to human SLC28A3 (solute carrier family 28 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 5.2), large intestine adult (RPKM 5.0) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 31.07 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (58701121..58758691, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (58553307..58610877, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)

General gene information

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Markers

BB284688 (e-PCR)
- UniSTS:208943

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Slc28a3 (e-PCR), detects polymorphism
- UniSTS:547327

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nucleoside transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables purine-specific nucleoside:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables purine-specific nucleoside:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables pyrimidine- and adenosine-specific:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyrimidine- and adenosine-specific:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables uridine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in nucleoside transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in purine nucleoside transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within purine nucleoside transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in pyrimidine nucleoside transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pyrimidine nucleoside transport	IDA Inferred from Direct Assay more info	PubMed
involved_in pyrimidine-containing compound transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in retina homeostasis	ISO Inferred from Sequence Orthology more info
involved_in uridine transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: solute carrier family 28 member 3

Names: CNT 3; concentrative Na(+)-nucleoside cotransporter 3; concentrative Na+-nucleoside cotransporter; mCNT3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022317.3 → NP_071712.3 solute carrier family 28 member 3

See identical proteins and their annotated locations for NP_071712.3

Status: VALIDATED

Source sequence(s)

AC154222, AF305211, BY736278

Consensus CDS

CCDS26572.1

UniProtKB/Swiss-Prot

Q3UM72, Q8BWE2, Q91VD7, Q9ERH8

Related

ENSMUSP00000022036.8, ENSMUST00000022036.14

Conserved Domains (4) summary

TIGR00804
Location:216 → 627

nupC; nucleoside transporter

pfam01773
Location:221 → 290

Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus

pfam07662
Location:403 → 627

Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus

pfam07670
Location:302 → 398

Gate; Nucleoside recognition